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降解多糖对禽白血病病毒 J 亚群的抗病毒活性。

Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from .

机构信息

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.

Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China.

出版信息

Biomed Res Int. 2018 Aug 5;2018:9415965. doi: 10.1155/2018/9415965. eCollection 2018.

DOI:10.1155/2018/9415965
PMID:30155485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6098872/
Abstract

Avian Leukosis Virus Subgroup J (ALV-J), a retrovirus of avian, has caused enormous economics losses to poultry industry around the world. Polysaccharides from marine algae are featured diversity bioactivities. To find the potential effect to prevent ALV-J spread, in this study, polysaccharides from (UPPs) and four low molecular weight (Mw) polysaccharides (LUPPs) were prepared and their functions on ALV-J were investigated. Firstly, LUPPs were obtained by hydrogen peroxide (HO) oxidative degradation. The effects of degradation conditions on Mw of the UPP were also investigated. Results showed that the HO oxidative degradation method could degrade UPP effectively, and the degradation was positively related to HO concentration and temperature and negatively to pH. The chemical characteristics of UPP and LUPPs were also determined. Afterwards, the anti-ALV-J activity of the polysaccharides were carried out in vitro. Results showed that UPP and LUPPs could inhibit ALV-J and LUPP-3 and Mw of 4.3 kDa exerted the strongest suppression. The action phase assay showed that LUPP-3 could bind with the viral particles and prevented ALV-J adsorption onto the host cells. And the ALV-J relative gene and gp85 protein expression were significantly suppressed after being administration with LUPP-3. Therefore, the low Mw polysaccharides from have great potential as an anti-ALV-J drug alternative.

摘要

禽白血病病毒 J 亚群（ALV-J）是一种禽类的逆转录病毒，它给全世界的家禽养殖业造成了巨大的经济损失。海洋藻类多糖具有多样性的生物活性。为了寻找预防 ALV-J 传播的潜在作用，本研究制备了（UPPs）和四种低分子量（Mw）多糖（LUPPs），并研究了它们对 ALV-J 的作用。首先，通过过氧化氢（HO）氧化降解法获得 LUPPs。还研究了降解条件对 UPP Mw 的影响。结果表明，HO 氧化降解法能有效降解 UPP，降解与 HO 浓度、温度呈正相关，与 pH 值呈负相关。还测定了 UPP 和 LUPPs 的化学特性。随后，在体外进行了多糖的抗 ALV-J 活性试验。结果表明，UPP 和 LUPPs 能抑制 ALV-J，而 Mw 为 4.3 kDa 的 LUPP-3 抑制作用最强。作用阶段分析表明，LUPP-3 能与病毒颗粒结合，阻止 ALV-J 吸附到宿主细胞上。并且在用 LUPP-3 处理后，ALV-J 相对基因和 gp85 蛋白的表达明显受到抑制。因此，来自 的低 Mw 多糖具有作为抗 ALV-J 药物替代物的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/3aa6ade9c77c/BMRI2018-9415965.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/86a7891dccc6/BMRI2018-9415965.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/9de4f791bc61/BMRI2018-9415965.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/173891ca94cf/BMRI2018-9415965.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/67e2407a81a3/BMRI2018-9415965.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/f5dce3fa144e/BMRI2018-9415965.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/d74384bf75cc/BMRI2018-9415965.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/76691e2e312b/BMRI2018-9415965.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/ca229e5eef7a/BMRI2018-9415965.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/3aa6ade9c77c/BMRI2018-9415965.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/86a7891dccc6/BMRI2018-9415965.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/9de4f791bc61/BMRI2018-9415965.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/173891ca94cf/BMRI2018-9415965.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/67e2407a81a3/BMRI2018-9415965.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/f5dce3fa144e/BMRI2018-9415965.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/d74384bf75cc/BMRI2018-9415965.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/76691e2e312b/BMRI2018-9415965.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/ca229e5eef7a/BMRI2018-9415965.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aaf/6098872/3aa6ade9c77c/BMRI2018-9415965.009.jpg

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