Yan Xiaoli, Li Xiao, Miao Mingsan
Pharmacology Specialty, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
Saudi Pharm J. 2017 May;25(4):504-508. doi: 10.1016/j.jsps.2017.04.014. Epub 2017 Apr 21.
Through the study of the effect of different ratio of Astragalus Total Saponins (ATS) and curcumin on Diabetes Mellitu (DM) model rats, we want to improve the screening model of the distribution ratio in Chinese Medicine, screening out the optimal proportion of the prevention and control of DM. By injecting streptozotocin (STZ) in the tail vein of rats to induct the DM rats model, we measured the dynamic change, insulin and insulin antibody (IAA) levels, glycosylated serum protein (GSP) content, lipid metabolism and the changes of renal pathology in DM model rats. The different distribution ratio of ATS and Curcumin can significantly reduce GSP, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL); significantly increased serum insulin levels and high density lipoprotein (HDL) content, significantly decreased IAA level on the DM rats model induced by STZ. Different proportions of ATS and Curcumin have a good therapeutic effect on DM model rats, and 6:4 is the optimal proportion for the prevention and treatment of DM.
通过研究不同比例的黄芪总皂苷（ATS）与姜黄素对糖尿病（DM）模型大鼠的影响，旨在改进中药配比筛选模型，筛选出防治DM的最佳比例。通过尾静脉注射链脲佐菌素（STZ）诱导大鼠DM模型，测定DM模型大鼠的动态变化、胰岛素及胰岛素抗体（IAA）水平、糖化血清蛋白（GSP）含量、脂质代谢及肾脏病理变化。ATS与姜黄素的不同配比可显著降低STZ诱导的DM大鼠模型的GSP、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL）；显著提高血清胰岛素水平及高密度脂蛋白（HDL）含量，显著降低IAA水平。不同比例的ATS与姜黄素对DM模型大鼠有良好的治疗作用，6:4为防治DM的最佳比例。
