化疗后睾丸癌患者的睾酮水平
Testosterone Level in Testicular Cancer Patients after Chemotherapy.
作者信息
Sarfraz M, Ashraf Y, Sajid S, Ashraf M A
机构信息
Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan. E-mail:
Department of Zoology, University of Punjab, Lahore, Pakistan.
出版信息
West Indian Med J. 2015 Dec;64(5):487-494. doi: 10.7727/wimj.2016.060. Epub 2016 Apr 29.
Abstract
BACKGROUND
The use of chemotherapy for the treatment of cancer began at the start of the 20 century in an attempt to narrow the universe of chemicals that affect the disease. Metastatic testicular cancer has always been sensitive to chemotherapy.
SUBJECTS AND METHOD
A retrospective and prospective study was performed of patients who had undergone testicular cancer from 2011-2013. The overall age of the testicular cancer patients at the time of diagnosis, their marital status, stage of disease and treatment strategies, testosterone level were analysed using linear regression and -test.
RESULTS
Most of the patients had seminoma tumour. A greater number of patients were diagnosed in the later stages of the disease. Before chemotherapy, testosterone level was normal and decreased during chemotherapy but after completion, it returned to normal level.
CONCLUSION
There is an early onset of testicular cancer in the Pakistani population. There is no effect of chemotherapy on testosterone production in late survivors.
摘要
背景
20世纪初开始使用化疗治疗癌症，旨在筛选出对该疾病有作用的化学物质。转移性睾丸癌一直对化疗敏感。
研究对象与方法
对2011年至2013年期间接受睾丸癌治疗的患者进行回顾性和前瞻性研究。使用线性回归和t检验分析睾丸癌患者诊断时的总体年龄、婚姻状况、疾病分期、治疗策略以及睾酮水平。
结果
大多数患者患有精原细胞瘤。更多患者在疾病晚期被诊断出来。化疗前，睾酮水平正常，化疗期间下降，但化疗结束后恢复到正常水平。
结论
巴基斯坦人群中睾丸癌发病较早。化疗对晚期幸存者的睾酮生成没有影响。
相似文献
1
Testosterone Level in Testicular Cancer Patients after Chemotherapy.化疗后睾丸癌患者的睾酮水平
West Indian Med J. 2015 Dec;64(5):487-494. doi: 10.7727/wimj.2016.060. Epub 2016 Apr 29.
2
Baseline characteristics and patterns of care in testicular cancer patients: first data from the Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS).睾丸癌患者的基线特征与护理模式：来自瑞士-奥地利-德国睾丸癌队列研究（SAG TCCS）的首批数据。
Swiss Med Wkly. 2018 Jul 24;148:w14640. doi: 10.4414/smw.2018.14640. eCollection 2018.
3
Long-term follow-up of boys who have undergone a testicular biopsy for fertility preservation.对因生育力保存而接受睾丸活检的男孩进行的长期随访。
Hum Reprod. 2021 Jan 1;36(1):26-39. doi: 10.1093/humrep/deaa281.
4
Insulin-like factor 3, luteinizing hormone and testosterone in testicular cancer patients: effects of β-hCG and cancer treatment.胰岛素样因子 3、黄体生成素和睾丸癌患者的睾酮：β-hCG 和癌症治疗的影响。
Andrology. 2019 Jul;7(4):441-448. doi: 10.1111/andr.12581. Epub 2019 Jan 4.
5
Management trends in stage I testicular seminoma: Impact of race, insurance status, and treatment facility.Ⅰ期睾丸精原细胞瘤的管理趋势：种族、保险状况和治疗机构的影响。
Cancer. 2015 Mar 1;121(5):681-7. doi: 10.1002/cncr.29094. Epub 2014 Oct 24.
6
Fertility, gonadal and sexual function in survivors of testicular cancer.睾丸癌幸存者的生育能力、性腺及性功能
Br J Cancer. 2005 Jul 25;93(2):200-7. doi: 10.1038/sj.bjc.6602677.
7
Testicular germ cell tumors in patients with human immunodeficiency virus infection.感染人类免疫缺陷病毒患者的睾丸生殖细胞肿瘤
Cancer. 1996 May 15;77(10):2109-16. doi: 10.1002/(SICI)1097-0142(19960515)77:10<2109::AID-CNCR22>3.0.CO;2-Y.
8
Testicular dysfunction at diagnosis in children and teenagers with haematopoietic malignancies improves after initial chemotherapy.儿童和青少年血液恶性肿瘤患者在诊断时的睾丸功能障碍在初始化疗后会得到改善。
Front Endocrinol (Lausanne). 2023 May 16;14:1135467. doi: 10.3389/fendo.2023.1135467. eCollection 2023.
9
Therapeutic exposures and pubertal testicular dysfunction are associated with adulthood milestones and paternity after childhood cancer.治疗性暴露和青春期睾丸功能障碍与儿童癌症后成年期的里程碑和生育能力有关。
Cancer. 2023 Nov 15;129(22):3633-3644. doi: 10.1002/cncr.34971. Epub 2023 Aug 8.
10
Longitudinal Changes in Serum Levels of Testosterone and Luteinizing Hormone in Testicular Cancer Patients after Orchiectomy Alone or Bleomycin, Etoposide, and Cisplatin.单纯睾丸切除术或博来霉素、依托泊苷和顺铂治疗后睾丸癌患者血清睾酮和黄体生成素水平的纵向变化。
Eur Urol Focus. 2018 Jul;4(4):591-598. doi: 10.1016/j.euf.2016.11.018. Epub 2016 Dec 15.
引用本文的文献
1
Testicular Cancer in Saudi Arabia Between 2004 and 2017.2004年至2017年沙特阿拉伯的睾丸癌
Res Rep Urol. 2023 Jan 24;15:37-45. doi: 10.2147/RRU.S393819. eCollection 2023.
2
Effect of Nano-Titanium Dioxide on Blood-Testis Barrier and MAPK Signaling Pathway in Male Mice.纳米二氧化钛对雄性小鼠血睾屏障及 MAPK 信号通路的影响。
Biol Trace Elem Res. 2021 Aug;199(8):2961-2971. doi: 10.1007/s12011-020-02404-4. Epub 2020 Sep 29.
3
Acitretin modulates HaCaT cells proliferation through STAT1- and STAT3-dependent signaling.阿维A通过依赖STAT1和STAT3的信号传导调节HaCaT细胞增殖。
Saudi Pharm J. 2017 May;25(4):620-624. doi: 10.1016/j.jsps.2017.04.034. Epub 2017 May 8.
4
Effects of the Rabdosia rubescens total flavonoids on focal cerebral ischemia reperfusion model in rats.冬凌草总黄酮对大鼠局灶性脑缺血再灌注模型的影响。
Saudi Pharm J. 2017 May;25(4):607-614. doi: 10.1016/j.jsps.2017.04.032. Epub 2017 Apr 28.
5
Effect of Motherwort total alkaloids on the prostate hyperplasia mice model of pathological changes of related tissue morphology induced by the fetal urogenital sinus implants.益母草总生物碱对胎鼠泌尿生殖窦植入诱导的前列腺增生小鼠模型相关组织形态病理变化的影响。
Saudi Pharm J. 2017 May;25(4):601-606. doi: 10.1016/j.jsps.2017.04.030. Epub 2017 May 7.
6
The first multiplication atom-bond connectivity index of molecular structures in drugs.药物分子结构的一阶乘法原子键连接性指数。
Saudi Pharm J. 2017 May;25(4):548-555. doi: 10.1016/j.jsps.2017.04.021. Epub 2017 Apr 28.
7
Optimization extraction and bioactivities of polysaccharide from wild .野生多糖的优化提取及生物活性
Saudi Pharm J. 2017 May;25(4):523-530. doi: 10.1016/j.jsps.2017.04.018. Epub 2017 Apr 28.
8
The intervention effect of different distribution ratio of Astragalus total saponins and curcumin on the DM rats model.黄芪总皂苷与姜黄素不同配比干预对糖尿病大鼠模型的影响
Saudi Pharm J. 2017 May;25(4):504-508. doi: 10.1016/j.jsps.2017.04.014. Epub 2017 Apr 21.
9
Investigation on the immunomodulatory activities of extracts in a cyclophosphamide (CTX)-induced immunosuppressanted mouse model.在环磷酰胺（CTX）诱导的免疫抑制小鼠模型中对提取物的免疫调节活性进行研究。
Saudi Pharm J. 2017 May;25(4):460-463. doi: 10.1016/j.jsps.2017.04.006. Epub 2017 Apr 21.
本文引用的文献
1
The quality of life and hormonal disturbances in testicular cancer survivors in Cisplatin era.顺铂时代睾丸癌幸存者的生活质量与激素紊乱
Eur Urol. 2007 Nov;52(5):1448-54. doi: 10.1016/j.eururo.2007.05.012. Epub 2007 May 25.
2
Refining the optimal chemotherapy regimen for good-risk metastatic nonseminomatous germ-cell tumors: a randomized trial of the Genito-Urinary Group of the French Federation of Cancer Centers (GETUG T93BP).优化低危转移性非精原细胞瘤生殖细胞肿瘤的最佳化疗方案：法国癌症中心联合会泌尿生殖组（GETUG T93BP）的一项随机试验
Ann Oncol. 2007 May;18(5):917-24. doi: 10.1093/annonc/mdm062. Epub 2007 Mar 9.
3
Completion and toxicity of induction chemotherapy for metastatic testicular cancer: an updated evaluation of Japanese patients.转移性睾丸癌诱导化疗的完成情况及毒性：日本患者的最新评估
Jpn J Clin Oncol. 2006 Jul;36(7):425-31. doi: 10.1093/jjco/hyl053. Epub 2006 Jun 20.
4
Cancer profile of Hyderabad, Pakistan 1998-2002.1998 - 2002年巴基斯坦海得拉巴市的癌症概况
Asian Pac J Cancer Prev. 2005 Oct-Dec;6(4):474-80.
5
Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality.22个欧洲国家睾丸癌发病率和死亡率的趋势：发病率持续上升，死亡率持续下降。
Int J Cancer. 2006 Jun 15;118(12):3099-111. doi: 10.1002/ijc.21747.
6
Increased incidence of testicular cancer in men presenting with infertility and abnormal semen analysis.在患有不育症且精液分析异常的男性中，睾丸癌发病率增加。
J Urol. 2005 Nov;174(5):1819-22; discussion 1822. doi: 10.1097/01.ju.0000177491.98461.aa.
7
Increasing incidence of testicular germ cell tumors among black men in the United States.美国黑人男性睾丸生殖细胞肿瘤发病率上升。
J Clin Oncol. 2005 Aug 20;23(24):5757-61. doi: 10.1200/JCO.2005.08.227.
8
Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial.放疗与单剂量卡铂辅助治疗Ⅰ期精原细胞瘤的随机试验
Lancet. 2005;366(9482):293-300. doi: 10.1016/S0140-6736(05)66984-X.
9
Fertility patterns prior to testicular cancer diagnosis.睾丸癌诊断前的生育模式。
Cancer Causes Control. 2005 Apr;16(3):295-9. doi: 10.1007/s10552-004-4024-2.
10
The changing presentation of germ cell tumours of the testis between 1983 and 2002.1983年至2002年间睾丸生殖细胞肿瘤表现的变化
BJU Int. 2005 Jun;95(9):1197-200. doi: 10.1111/j.1464-410X.2005.05504.x.
Zotero 插件