Sarfraz M, Ashraf Y, Sajid S, Ashraf M A
Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan. E-mail:
Department of Zoology, University of Punjab, Lahore, Pakistan.
West Indian Med J. 2015 Dec;64(5):487-494. doi: 10.7727/wimj.2016.060. Epub 2016 Apr 29.
The use of chemotherapy for the treatment of cancer began at the start of the 20 century in an attempt to narrow the universe of chemicals that affect the disease. Metastatic testicular cancer has always been sensitive to chemotherapy.
A retrospective and prospective study was performed of patients who had undergone testicular cancer from 2011-2013. The overall age of the testicular cancer patients at the time of diagnosis, their marital status, stage of disease and treatment strategies, testosterone level were analysed using linear regression and -test.
Most of the patients had seminoma tumour. A greater number of patients were diagnosed in the later stages of the disease. Before chemotherapy, testosterone level was normal and decreased during chemotherapy but after completion, it returned to normal level.
There is an early onset of testicular cancer in the Pakistani population. There is no effect of chemotherapy on testosterone production in late survivors.
20世纪初开始使用化疗治疗癌症，旨在筛选出对该疾病有作用的化学物质。转移性睾丸癌一直对化疗敏感。
对2011年至2013年期间接受睾丸癌治疗的患者进行回顾性和前瞻性研究。使用线性回归和t检验分析睾丸癌患者诊断时的总体年龄、婚姻状况、疾病分期、治疗策略以及睾酮水平。
大多数患者患有精原细胞瘤。更多患者在疾病晚期被诊断出来。化疗前，睾酮水平正常，化疗期间下降，但化疗结束后恢复到正常水平。
巴基斯坦人群中睾丸癌发病较早。化疗对晚期幸存者的睾酮生成没有影响。
