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机会致病菌还是无辜旁观者?一例半乳甘露聚糖交叉反应的病例分析及演示

: Opportunistic pathogen or idle bystander? A case analysis with demonstration of galactomannan cross-reactivity.

作者信息

Hesse Shayla E, Luethy Paul M, Beigel John H, Zelazny Adrian M

机构信息

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA.

出版信息

Med Mycol Case Rep. 2017 May 22;17:8-10. doi: 10.1016/j.mmcr.2017.05.003. eCollection 2017 Sep.

DOI:10.1016/j.mmcr.2017.05.003
PMID:28580236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5447564/
Abstract

We present a case of an immunocompromised woman with fever, pulmonary infiltrates and multiple bronchoalveolar lavage (BAL) cultures positive for with a concomitant high BAL galactomannan level. We report the results of galactomannan testing performed on culture supernatants from her strain that confirmed the suspected cross-reactivity. Finally, we discuss the clinical significance and antifungal susceptibility of in our case and review the literature.

摘要

我们报告一例免疫功能低下的女性患者,其有发热、肺部浸润,多次支气管肺泡灌洗(BAL)培养对[具体真菌名称未给出]呈阳性,同时BAL半乳甘露聚糖水平升高。我们报告了对其[具体真菌名称未给出]菌株培养上清液进行半乳甘露聚糖检测的结果,证实了疑似交叉反应。最后,我们讨论了本例中[具体真菌名称未给出]的临床意义和抗真菌药敏情况,并复习了相关文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc4/5447564/05ff28ef307c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc4/5447564/05ff28ef307c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc4/5447564/05ff28ef307c/gr1.jpg

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Identification and Antifungal Susceptibility of Penicillium-Like Fungi from Clinical Samples in the United States.美国临床样本中类青霉属真菌的鉴定及抗真菌药敏性
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2
Identification and nomenclature of the genus Penicillium.青霉属的鉴定与命名
Stud Mycol. 2014 Jun;78:343-71. doi: 10.1016/j.simyco.2014.09.001.
3
Reduction in false-positive Aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States.
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J Clin Microbiol. 2014 Jun;52(6):2199-201. doi: 10.1128/JCM.00285-14. Epub 2014 Apr 9.
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Crit Rev Microbiol. 2015 Feb;41(1):124-34. doi: 10.3109/1040841X.2013.804033. Epub 2013 Jun 25.
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Cross-reactivity of Fusarium spp. in the Aspergillus Galactomannan enzyme-linked immunosorbent assay.镰刀菌属在曲霉半乳甘露聚糖酶联免疫吸附试验中的交叉反应性。
J Clin Microbiol. 2012 Mar;50(3):1051-3. doi: 10.1128/JCM.05946-11. Epub 2012 Jan 11.
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Aspergillus galactomannan antigenemia in penicilliosis marneffei.马尔尼菲青霉病中的曲霉半乳甘露聚糖抗原血症
AIDS. 2007 Sep 12;21(14):1990-1. doi: 10.1097/QAD.0b013e3282eeb413.
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