Carr Brian I, Guerra Vito, Giannini Edoardo G, Farinati Fabio, Ciccarese Francesca, Rapaccini Gian Ludovico, Di Marco Maria, Benvegnù Luisa, Zoli Marco, Borzio Franco, Caturelli Eugenio, Masotto Alberto, Trevisani Franco
Izmir Biomedicine and Genome Center, Dokuz Eylul University, Turkey and Lusaka Apex Medical University, Zambia.
Department of Clinical Trials and Epidemiology, IRCCS de Bellis, Castellana Grotte, Italy.
J Integr Oncol. 2016 Oct;5(4). doi: 10.4172/2329-6771.1000178. Epub 2016 Sep 5.
A Hepatocellular (HCC) Aggressiveness Index was recently constructed, consisting of the sum of the scores for the 4 clinical parameters of maximum tumor size, multifocality, presence of portal vein thrombus and blood alphafetoprotein levels. It was observed that there was an association with several liver function tests. We have now formed a Liver Index from the 4 liver parameters with the highest hazard ratios with respect to HCC aggressiveness, namely: blood total bilirubin, gamma glutamyl transpeptidase (GGTP), albumin and platelet levels (cirrhosis surrogate). We found that the scores for the Liver Index related significantly to survival, but also to the Aggressiveness Index and to its individual HCC components as well as showing significant trends with the components. These results support the hypothesis that liver function is not only an important prognostic factor in HCC patients, but may also be involved in HCC biology and aggressiveness. Blood albumin, GGTP, albumin and platelet levels were used to create a Liver Index that related significantly to parameters of HCC aggressiveness.
最近构建了一个肝细胞癌（HCC）侵袭性指数，它由最大肿瘤大小、多灶性、门静脉血栓形成和血液甲胎蛋白水平这4个临床参数的得分总和组成。据观察，它与多项肝功能检查存在关联。我们现在根据与HCC侵袭性具有最高风险比的4个肝脏参数形成了一个肝脏指数，即：血液总胆红素、γ-谷氨酰转肽酶（GGTP）、白蛋白和血小板水平（肝硬化替代指标）。我们发现肝脏指数得分与生存率显著相关，也与侵袭性指数及其各个HCC组成部分显著相关，并且与这些组成部分呈现出显著趋势。这些结果支持了这样一种假说，即肝功能不仅是HCC患者的一个重要预后因素，而且可能还参与了HCC的生物学特性和侵袭性。血液白蛋白、GGTP、白蛋白和血小板水平被用于创建一个与HCC侵袭性参数显著相关的肝脏指数。
