Carr Brian I, Guerra Vito
Izmir Biomedicine and Genome Center, Dokuz Eylul University, Izmir, Turkey.
Department of Clinical Trials, IRCCS de Bellis, Castellana Grotte, Italy.
J Gastrointest Cancer. 2017 Sep;48(3):262-266. doi: 10.1007/s12029-017-9971-4.
We recently constructed a liver index (LI) from four liver parameters, namely: blood total bilirubin, gamma glutamyl transpeptidase (GGTP), albumin, and platelet levels (a cirrhosis surrogate). We found that the scores for the liver index related significantly to a four-parameter HCC aggressiveness index (maximum tumor diameter, multifocality, percent portal vein invasion, and blood AFP levels).
To validate the relationship of liver parameters to tumor aggressiveness parameters in a larger, different HCC dataset.
We now confirm these associations in another large HCC cohort. Furthermore, this liver index showed significant trends with the individual HCC aggressiveness parameters.
These results provide further support for the idea that liver microenvironment, as reflected in liver function tests, may relate to HCC behavior.
我们最近根据四个肝脏参数构建了一个肝脏指数（LI），这四个参数分别为：血液总胆红素、γ-谷氨酰转肽酶（GGTP）、白蛋白和血小板水平（肝硬化替代指标）。我们发现肝脏指数得分与一个四参数肝癌侵袭性指数（最大肿瘤直径、多灶性、门静脉侵犯百分比和血液甲胎蛋白水平）显著相关。
在一个更大的、不同的肝癌数据集中验证肝脏参数与肿瘤侵袭性参数之间的关系。
我们现在在另一个大型肝癌队列中证实了这些关联。此外，这个肝脏指数与各个肝癌侵袭性参数呈现出显著趋势。
这些结果为以下观点提供了进一步支持，即肝功能检查所反映的肝脏微环境可能与肝癌行为有关。
