间充质干细胞移植对不同年龄自发性高血压大鼠软脑膜微血管网络密度的影响
Effect of Transplantation of Mesenchymal Stem Cells on the Density of Pial Microvascular Network in Spontaneously Hypertensive Rats of Different Age.
作者信息
Sokolova I B, Sergeev I V, Skorobogataya E V, Ufimtseva A N, Polyntsev D G, Dvoretskii D P
机构信息
Laboratory of Physiology of Cardiovascular and Lymphatic Systems, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Trans-Tekhnologii Company, St. Petersburg, Russia.
出版信息
Bull Exp Biol Med. 2017 May;163(1):129-132. doi: 10.1007/s10517-017-3752-8. Epub 2017 Jun 3.
Using a TV device for studying microcirculation (×40), we analyzed the density of the whole microvascular network and the density of arterioles in the pia mater of the sensorimotor cortex in SHR rats of different ages (3-4 and 12 months) after intracerebral transplantation of human mesenchymal stem cells. We found that the density of pial microvascular network in SHR rats receiving transplantation of human mesenchymal stem cells increased to a level observed in young Wistar-Kyoto rats.
我们使用电视设备（放大倍数为×40）研究微循环，分析了不同年龄（3 - 4个月和12个月）的自发性高血压大鼠（SHR）在脑内移植人间充质干细胞后，感觉运动皮层软脑膜中整个微血管网络的密度和小动脉的密度。我们发现，接受人间充质干细胞移植的SHR大鼠软脑膜微血管网络的密度增加到了年轻的Wistar - Kyoto大鼠所观察到的水平。
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