患有抑郁症的阿尔茨海默病患者的异常基线脑活动：一项静息态功能磁共振成像研究。
Abnormal baseline brain activity in Alzheimer's disease patients with depression: a resting-state functional magnetic resonance imaging study.
作者信息
Liu Xiaozheng, Guo Zhongwei, Ding Yanping, Li Jiapeng, Wang Gang, Hou Hongtao, Chen Xingli, Yu Enyan
机构信息
China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.
出版信息
Neuroradiology. 2017 Jul;59(7):709-714. doi: 10.1007/s00234-017-1854-7. Epub 2017 Jun 3.
PURPOSE
As one of the most common mental disorders and the most important precursor of suicide in Alzheimer's disease (AD), depression is associated with a decline in both well-being and daily functioning. At present, the diagnosis of AD patients with depression (D-AD) is largely dependent on clinical signs and symptoms, and the precise neural correlate underlying D-AD is still not fully understood.
METHODS
The current study sought to investigate low-frequency oscillations at the voxel level in D-AD patients based on the amplitude of low-frequency fluctuations (ALFF) measured using resting-state functional magnetic resonance imaging. We examined 22 D-AD patients and 21 non-depressed AD (nD-AD) patients.
RESULTS
The results revealed that D-AD patients exhibited increased ALFF values in the left caudate and thalamus and decreased ALFF values in the left middle temporal pole compared with nD-AD patients.
CONCLUSION
These findings may provide further insight into the underlying neuropathophysiology of AD with depression.
目的
作为阿尔茨海默病（AD）中最常见的精神障碍之一以及自杀的最重要先兆，抑郁症与幸福感和日常功能下降相关。目前，AD合并抑郁症（D-AD）患者的诊断很大程度上依赖于临床体征和症状，而D-AD潜在的精确神经关联仍未完全明确。
方法
本研究旨在基于静息态功能磁共振成像测量的低频波动幅度（ALFF），在体素水平研究D-AD患者的低频振荡。我们检查了22例D-AD患者和21例非抑郁AD（nD-AD）患者。
结果
结果显示，与nD-AD患者相比，D-AD患者左侧尾状核和丘脑的ALFF值增加，左侧颞中极的ALFF值降低。
结论
这些发现可能为AD合并抑郁症的潜在神经病理生理学提供进一步的见解。
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