Merkt Helene, Sadeghi Bahmani Dena, Calabrese Pasquale, Naegelin Yvonne, Gerber Markus, Pühse Uwe, Holsboer-Trachsler Edith, Brand Serge
2 Division of Molecular and Cognitive Neurosciences, Faculty of Psychology, University of Basel, Basel, Switzerland.
1 Psychiatric Clinics (UPK), Center for Affective, Stress and Sleep Disorders (ZASS), University of Basel, Basel, Switzerland.
Percept Mot Skills. 2017 Oct;124(5):974-991. doi: 10.1177/0031512517711851. Epub 2017 Jun 5.
This study investigated the interrelatedness of physical disability, physical activity, and depression among patients with multiple sclerosis (MS). We hypothesized that self-reported physical activity would mediate the effect of disability on depressive symptoms. Twenty-seven patients with MS (mean age: 49 years; 44.5% females) completed self-rating scales covering sociodemographic variables, intake of antidepressants, physical activity, and symptoms of depression; disability was measured by the Expanded Disability Status Scale. We found a higher level of disability to be significantly associated with more symptoms of depression. While higher reported physical activity was descriptively associated with lower depression scores and unrelated to Expanded Disability Status Scale, physical activity levels did not mediate the effect of disability on depressive symptoms.
本研究调查了多发性硬化症（MS）患者身体残疾、身体活动与抑郁之间的相关性。我们假设自我报告的身体活动会介导残疾对抑郁症状的影响。27名MS患者（平均年龄：49岁；44.5%为女性）完成了涵盖社会人口统计学变量、抗抑郁药摄入量、身体活动和抑郁症状的自评量表；残疾程度通过扩展残疾状态量表进行测量。我们发现较高的残疾水平与更多的抑郁症状显著相关。虽然较高的身体活动报告量在描述上与较低的抑郁评分相关，且与扩展残疾状态量表无关，但身体活动水平并未介导残疾对抑郁症状的影响。
