Jeong Kyoung Sook, Park Hyewon, Ha Eunhee, Shin Jiyoung, Hong Yun Chul, Ha Mina, Park Hyesook, Kim Bung Nyun, Lee Boeun, Lee Soo Jeong, Lee Kyung Yeon, Kim Ja Hyeong, Kim Yangho
Department of Occupational and Environmental Medicine, Dongguk University College of Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.
Department of Child and Family Welfare, University of Ulsan, Ulsan, Korea.
J Korean Med Sci. 2017 Jul;32(7):1097-1104. doi: 10.3346/jkms.2017.32.7.1097.
The objective of the present study was to investigate the relationship of IQ in children with maternal blood mercury concentration during late pregnancy. The present study is a component of the Mothers and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 553 children whose mothers underwent testing for blood mercury during late pregnancy. The children were given the Korean language version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R) at 60 months of age. Multivariate linear regression analysis, with adjustment for covariates, was used to assess the relationship between verbal, performance, and total IQ in children and blood mercury concentration of mothers during late pregnancy. The results of multivariate linear regression analysis indicated that a doubling of blood mercury was associated with the decrease in verbal and total IQ by 2.482 (95% confidence interval [CI], 0.749-4.214) and 2.402 (95% CI, 0.526-4.279), respectively, after adjustment. This inverse association remained after further adjustment for blood lead concentration. Fish intake is an effect modifier of child IQ. In conclusion, high maternal blood mercury level is associated with low verbal IQ in children.
本研究的目的是调查妊娠晚期孕妇血汞浓度与儿童智商之间的关系。本研究是韩国于2006年启动的多中心出生队列项目“母婴环境健康（MOCEH）研究”的一部分。研究队列包括553名儿童，他们的母亲在妊娠晚期接受了血汞检测。这些儿童在60个月大时接受了韦氏学前及初小儿童智力测验修订版（WPPSI-R）韩语版测试。采用多变量线性回归分析，并对协变量进行调整，以评估儿童的语言、操作和总智商与妊娠晚期母亲血汞浓度之间的关系。多变量线性回归分析结果表明，调整后血汞浓度翻倍分别与语言智商和总智商降低2.482（95%置信区间[CI]，0.749 - 4.214）和2.402（95%CI，0.526 - 4.279）相关。在进一步调整血铅浓度后，这种负相关仍然存在。鱼类摄入量是儿童智商的一个效应修饰因素。总之，孕妇血汞水平高与儿童语言智商低有关。
