Sanchez N P, Van Hale H M, Su W P
Arch Dermatol. 1985 Feb;121(2):220-4.
Clinical and histopathologic features of 101 cases of necrotizing vasculitis were selected on the basis of the following histopathologic criteria: fibrinoid necrosis of blood vessel walls, endothelial cell hyperplasia, and an infiltrate within and around the blood vessel walls predominantly of polymorphonuclear leukocytes. There were three clinical patterns of vasculitis: (1) associated with other coexistent disease, (2) associated with known precipitating events, and (3) idiopathic. Two histologic features were particularly notable in view of the clinical findings. First, vasculitis extending deep into the reticular dermis or subcutaneous tissue seemed to be associated more often with systemic disease such as malignancy or connective tissue disease. Second, in biopsy specimens from patients with hypocomplementemia, the inflammatory infiltrate was composed almost exclusively of neutrophils, as compared with the mixed infiltrate seen in normocomplementemic vasculitis.
根据以下组织病理学标准选取了101例坏死性血管炎患者的临床和组织病理学特征：血管壁纤维蛋白样坏死、内皮细胞增生以及血管壁内及周围主要为多形核白细胞浸润。血管炎有三种临床类型：（1）与其他并存疾病相关；（2）与已知诱发事件相关；（3）特发性。鉴于临床发现，有两个组织学特征尤为显著。首先，深入网状真皮或皮下组织的血管炎似乎更常与恶性肿瘤或结缔组织病等全身性疾病相关。其次，与补体正常的血管炎中所见的混合浸润相比，低补体血症患者活检标本中的炎性浸润几乎完全由中性粒细胞组成。
