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生物可吸收支架:临床结果与考量

Bioresorbable Scaffolds: Clinical Outcomes and Considerations.

作者信息

Capodanno Davide

机构信息

Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, via Citelli 6, Catania 95124, Italy.

出版信息

Interv Cardiol Clin. 2016 Jul;5(3):357-363. doi: 10.1016/j.iccl.2016.02.005. Epub 2016 Jun 21.

Abstract

Bioresorbable scaffolds (BRS) have been engineered to eliminate the theoretic stimulus to late coronary events, a caveat of conventional metallic drug-eluting stents (DESs). Outcome benefits of BRSs over current-generation DESs are expected to accrue after complete bioresorption. Before this timeframe, BRSs need to prove at least similarly safe and effective compared with DESs. Several randomized studies of the Absorb BRS have been made available. Several manufacturers are at the beginning of their line of clinical development of competing BRSs. This article reviews the contemporary clinical outcomes of the Absorb scaffold, and provides an updated state of the art on the other players in the BRS arena.

摘要

生物可吸收支架(BRS)的设计旨在消除传统金属药物洗脱支架(DES)对晚期冠状动脉事件的理论刺激,这是传统金属药物洗脱支架的一个问题。预计在完全生物吸收后,BRS相对于当代DES会带来更好的结果。在此时间框架之前,BRS需要证明至少与DES一样安全有效。已经开展了几项关于Absorb BRS的随机研究。几家制造商正处于其竞争性BRS临床开发产品线的起步阶段。本文回顾了Absorb支架的当代临床结果,并提供了BRS领域其他产品的最新技术状态。

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