生长抑素与倾倒综合征。
Somatostatin and the dumping syndrome.
作者信息
Long R G, Adrian T E, Bloom S R
出版信息
Br Med J (Clin Res Ed). 1985 Mar 23;290(6472):886-8. doi: 10.1136/bmj.290.6472.886.
Abstract
Infusion of somatostatin reduced the symptoms of the early dumping syndrome after oral glucose was given and also reduced the associated tachycardia and rise in packed cell volume. It inhibited the secretion of enteroglucagon, neurotensin, and vasoactive intestinal polypeptide, which are raised in patients with the dumping syndrome and may have an aetiological role. It also prevented the reactive hypoglycaemia of late dumping by inhibiting the release of gastric inhibitory polypeptide and insulin. Somatostatin, possibly through its inhibitory effects on hormonal secretion, may have a role in the management of patients with the early and late dumping syndrome.
摘要
输注生长抑素可减轻口服葡萄糖后早期倾倒综合征的症状，还可减轻相关的心动过速及红细胞压积升高。它抑制肠高血糖素、神经降压素和血管活性肠肽的分泌，这些物质在倾倒综合征患者中升高，可能起病因学作用。它还通过抑制胃抑制性多肽和胰岛素的释放来预防晚期倾倒的反应性低血糖。生长抑素可能通过其对激素分泌的抑制作用，在早期和晚期倾倒综合征患者的管理中发挥作用。
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本文引用的文献
1
Elevation of plasma neurotensin in the dumping syndrome.倾倒综合征时血浆神经降压素水平升高。
Clin Sci (Lond). 1980 Oct;59(4):237-43. doi: 10.1042/cs0590237.
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Glicentin inhibits gastric acid secretion in the rat.胰高血糖素样肽抑制大鼠胃酸分泌。
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Release of vasoactive intestinal peptide in the dumping syndrome.倾倒综合征中血管活性肠肽的释放
Br Med J (Clin Res Ed). 1981 Feb 14;282(6263):507-10. doi: 10.1136/bmj.282.6263.507.
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Gut hormones.肠道激素
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Structure-activity relationships of somatostatin analogs in the rabbit ileum and the rat colon.生长抑素类似物在兔回肠和大鼠结肠中的构效关系。
J Clin Invest. 1983 Apr;71(4):840-9. doi: 10.1172/jci110838.
6
Effects of intravenous somatostatin and motilin on the blood glucose and hormonal response to oral glucose.静脉注射生长抑素和胃动素对口服葡萄糖后血糖及激素反应的影响。
Eur J Clin Invest. 1982 Aug;12(4):331-6. doi: 10.1111/j.1365-2362.1982.tb02241.x.
7
Effect of somatostatin on diarrhea and on small intestinal water and electrolyte transport in a patient with pancreatic cholera.生长抑素对胰性霍乱患者腹泻及小肠水和电解质转运的影响。
Dig Dis Sci. 1982 May;27(5):459-66. doi: 10.1007/BF01295657.
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The effect of somatostatin analogs on secretion of growth, pancreatic, and gastrointestinal hormones in man.生长抑素类似物对人体生长激素、胰液及胃肠激素分泌的影响。
J Clin Endocrinol Metab. 1981 Oct;53(4):675-81. doi: 10.1210/jcem-53-4-675.
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Effect of neurotensin on gastric function in man.神经降压素对人体胃功能的影响。
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