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用于在酿酒酵母中生产异源芳香化学品及其衍生物的途径工程:从葡萄糖的生物转化。

Pathway engineering for the production of heterologous aromatic chemicals and their derivatives in Saccharomyces cerevisiae: bioconversion from glucose.

机构信息

Institute of Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany. Tel: +49 69 798 29516; E-Mail:

出版信息

FEMS Yeast Res. 2017 Jun 1;17(4). doi: 10.1093/femsyr/fox035.

Abstract

Saccharomyces cerevisiae has been extensively engineered for optimising its performance as a microbial cell factory to produce valuable aromatic compounds and their derivatives as bulk and fine chemicals. The production of heterologous aromatic molecules in yeast is achieved via engineering of the aromatic amino acid biosynthetic pathway. This pathway is connected to two pathways of the central carbon metabolism, and is highly regulated at the gene and protein level. These characteristics impose several challenges for tailoring it, and various modifications need to be applied in order to redirect the carbon flux towards the production of the desired compounds. This minireview addresses the metabolic engineering approaches targeting the central carbon metabolism, the shikimate pathway and the tyrosine and phenylalanine biosynthetic pathway of S. cerevisiae for biosynthesis of aromatic chemicals and their derivatives from glucose.

摘要

酿酒酵母已被广泛用于优化其作为微生物细胞工厂的性能,以生产有价值的芳香族化合物及其衍生物作为大宗化学品和精细化学品。通过工程化芳香族氨基酸生物合成途径,在酵母中生产异源芳香族分子。该途径与中心碳代谢的两条途径相连,并在基因和蛋白质水平上受到高度调控。这些特性给其定制带来了一些挑战,需要进行各种修改,以将碳通量重新导向所需化合物的生产。本综述介绍了针对酿酒酵母的中心碳代谢、莽草酸途径和酪氨酸及苯丙氨酸生物合成途径的代谢工程方法,以从葡萄糖生物合成芳香族化合物及其衍生物。

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