Myers M G
Can Med Assoc J. 1985 Mar 15;132(6):644-8.
To determine the possible influence of studies on beta-blocker therapy following myocardial infarction and the introduction of calcium-channel blockers on the prescribing habits of physicians in a large urban centre, the drug therapy received by 100 patients with ischemic heart disease (IHD) (50 with myocardial infarction and 50 with unstable angina) admitted to a university teaching hospital in 1980 was compared with that received by another such group of 100 patients admitted in 1983-84. The proportion of patients with myocardial infarction receiving drug therapy was significantly higher in 1983-84, at the time of both admission (p less than 0.01) and discharge (p less than 0.001). Much of the increase was due to greater use of beta-blockers. Of the 50 patients with unstable angina in 1983-84, 20 were taking calcium-channel blockers when admitted, and 29 were taking them when discharged. In both 1980 and 1983-84 unstable angina was treated more vigorously than myocardial infarction. The results suggest that physicians have developed a more aggressive approach to drug therapy for IHD since the publication of the beta-blocker studies and the introduction of calcium-channel blockers.
为了确定心肌梗死后β受体阻滞剂治疗研究以及钙通道阻滞剂的引入对大城市中心医生处方习惯的可能影响，将1980年入住一所大学教学医院的100例缺血性心脏病（IHD）患者（50例心肌梗死患者和50例不稳定型心绞痛患者）接受的药物治疗与1983 - 1984年入住的另一组100例此类患者接受的药物治疗进行了比较。在1983 - 1984年，心肌梗死患者接受药物治疗的比例在入院时（p < 0.01）和出院时（p < 0.001）均显著更高。增加的部分主要是由于β受体阻滞剂的使用增加。在1983 - 1984年的50例不稳定型心绞痛患者中，20例入院时服用钙通道阻滞剂，29例出院时服用。在1980年和1983 - 1984年，不稳定型心绞痛的治疗都比心肌梗死更积极。结果表明，自β受体阻滞剂研究发表和钙通道阻滞剂引入以来，医生对IHD的药物治疗采取了更积极的方法。
