Bim可能是乳腺癌患者尤其是管腔A型肿瘤患者预后不良的生物标志物。

Bim may be a poor prognostic biomarker in breast cancer patients especially in those with luminal A tumors.

作者信息

Maimaiti Yusufu, Dong Lingling, Aili Aikebaier, Maimaitiaili Maimaitiaili, Huang Tao, Abudureyimu Kelimu

机构信息

Department of General Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.

Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

Cancer Biomark. 2017 Jul 4;19(4):411-418. doi: 10.3233/CBM-160377.

DOI:10.3233/CBM-160377

PMID:28582840

Abstract

BACKGROUND

Bcl-2 interacting mediator of cell death (Bim) appears to have contradictory roles in cancer. It is uncertain whether Bim show prognostic significance in patients with breast cancer.

OBJECTIVE

To investigate the correlation between Bim expression and clinicopathological characteristics of breast cancer and to evaluate Bim's effect on overall survival (OS).

METHODS

We used immunohistochemistry (IHC) technique to detect the expression of Bim via tissue microarray in 275 breast cancer samples, Kaplan-Meier analysis to perform survival analysis, and Cox proportional hazards regression model to explore the risk factors of breast cancer.

RESULTS

The results revealed that Bim expression was significantly correlated with age, estrogen receptor (ER) and/or progesterone receptor (PR), human epidermal growth factor receptor (HER2) and Ki67 expression (P< 0.05). Bim expression was significantly different in the four molecular subtypes (P= 0.000). Survival analysis showed that Bim positive expression contributed to a shorter OS (P= 0.034), especially in patients with luminal A tumors (P= 0.039). Univariate and multivariate regression analysis showed that Bim was an independent prognostic factor for breast cancer (P< 0.05).

CONCLUSION

Bim may serve as an effective predictive factor for lower OS in breast cancer patients, especially in those with luminal A tumors.

摘要

背景

细胞死亡的Bcl-2相互作用介质（Bim）在癌症中似乎具有矛盾的作用。Bim在乳腺癌患者中是否具有预后意义尚不确定。

目的

探讨Bim表达与乳腺癌临床病理特征之间的相关性，并评估Bim对总生存期（OS）的影响。

方法

我们采用免疫组织化学（IHC）技术，通过组织芯片检测275例乳腺癌样本中Bim的表达，采用Kaplan-Meier分析进行生存分析，并采用Cox比例风险回归模型探讨乳腺癌的危险因素。

结果

结果显示，Bim表达与年龄、雌激素受体（ER）和/或孕激素受体（PR）、人表皮生长因子受体（HER2）及Ki67表达显著相关（P<0.05）。Bim表达在四种分子亚型中存在显著差异（P=0.000）。生存分析表明，Bim阳性表达导致较短的总生存期（P=0.034），尤其是在腔面A型肿瘤患者中（P=0.039）。单因素和多因素回归分析表明，Bim是乳腺癌的独立预后因素（P<0.05）。