Yaxley Julian
Int J Risk Saf Med. 2016;28(4):189-196. doi: 10.3233/JRS-170735.
An association between non-opioid analgesic agents and chronic kidney disease has long been suspected. The presumed development of chronic renal impairment following protracted excessive use of non-opioid analgesia is known as analgesic nephropathy. Many accept analgesic nephropathy as a real entity despite a paucity of robust scientific evidence. The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol probably contribute to chronic renal impairment, however there is no convincing data to implicate non-steroidal anti-inflammatory drugs or aspirin monotherapy. While controversy persists most physicians consider all non-narcotic analgesics nephrotoxic and discourage heavy use where possible.
长期以来，人们一直怀疑非阿片类镇痛药与慢性肾脏病之间存在关联。长期过度使用非阿片类镇痛药后推测发生的慢性肾功能损害被称为镇痛剂肾病。尽管缺乏有力的科学证据，但许多人认为镇痛剂肾病是一种真实存在的疾病。现有观察性文献表明，长期服用对乙酰氨基酚以及阿司匹林和对乙酰氨基酚的复方制剂可能会导致慢性肾功能损害，然而，尚无令人信服的数据表明非甾体抗炎药或阿司匹林单药治疗与此有关。尽管争议仍然存在，但大多数医生认为所有非麻醉性镇痛药都具有肾毒性，并尽可能不鼓励大量使用。
