Mazidi Mohsen, Kengne Andre Pascal, Sahebkar Amirhossein, Banach Maciej
1 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
2 Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing, China.
Angiology. 2018 Feb;69(2):164-169. doi: 10.1177/0003319717712860. Epub 2017 Jun 6.
Telomere length (TL) has been associated with age-related health outcomes. We investigated the relationship of TL with cardiometabolic risk profile in adult Americans. We used the National Health and Nutrition Examination Surveys for 1999 to 2002, accounting for complex sampling and survey design. Of the 8892 eligible participants, 47.8% (n = 4123) were men. Mean serum high-density lipoprotein cholesterol concentrations significantly increased across increasing TL quarters ( P = .013), and mean fat mass, fat-free mass, hemoglobin A (HbA), and C-reactive protein significantly decreased across increasing TL quarters (all P < .001) in men. Only HbA levels significantly decreased across increasing TL quarters ( P = .041) in women. Males in the upper quarter of TL had lower (38%) odds of prevalent metabolic syndrome compared with those in the lower quarter ( P < .001). These results support the hypotheses that cardiometabolic factors are related to TL, especially in men.
端粒长度（TL）与年龄相关的健康结果有关。我们调查了美国成年人中TL与心脏代谢风险状况之间的关系。我们使用了1999年至2002年的国家健康和营养检查调查，并考虑了复杂的抽样和调查设计。在8892名符合条件的参与者中，47.8%（n = 4123）为男性。男性中，随着TL四分位数的增加，平均血清高密度脂蛋白胆固醇浓度显著升高（P = 0.013），而平均脂肪量、去脂体重、糖化血红蛋白A（HbA）和C反应蛋白则显著降低（所有P < 0.001）。在女性中，只有HbA水平随着TL四分位数的增加而显著降低（P = 0.041）。与TL处于较低四分位数的男性相比，TL处于较高四分位数的男性患代谢综合征的几率较低（38%）（P < 0.001）。这些结果支持了心脏代谢因素与TL相关的假设，尤其是在男性中。
