Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Institute of Genetics and Developmental Biology, International College, The University of Chinese Academy of Science, Beijing, 100101, China.
Eur J Clin Nutr. 2018 Apr;72(4):581-586. doi: 10.1038/s41430-017-0065-y. Epub 2018 Mar 2.
BACKGROUND/OBJECTIVES: To assess the relationship between plasma trans-fatty acids (TFAs) levels and leucocyte telomere length (TL) in a US adult population sample.
SUBJECTS/METHODS: National Health and Nutrition Examination Survey (NHANES) database was used for this study. Gas chromatography was used to separate derivatised fatty acids (Four major TFAs [palmitelaidic acid (C16:1n-7t), trans vaccenic acid (C18:1n-7t), elaidic acid (C18:1n-9t), and linoelaidic acid (C18:2n-6t,9t)]) which were then quatified using negative chemical ionization mass spectrometry. Data analyses used multivariable linear regressions, while accounting for the survey design.
A total of 5446 eligible participants, with 46.8% (n = 2550) being men, were included. Their average age was 47.1 years for the total sample, and 47.8 and 46.5 years in men and women respectively (p = 0.085 for men vs. women difference). Concentrations of palmitelaidic acid and linolelaidic acid decreased with increasing length of the telomere (p < 0.05). Univariable linear regressions revealed a significant negative association between levels of the palmitelaidic acid, elaidic acid, vaccenic acid, and linolelaidic acid with TL. However when models were adjusted for age, sex, ethnicity, education, marital status, sub-clinical inflammation, body mass index, and smoking, only palmitelaidic acid and linolelaidic acid remained significant (p < 0.05).
TFAs levels and particularly palmitelaidic and linolelaidic acids, are likely negatively associated with telomere lenght. Future studies should explore the potential implications of these associations.
背景/目的：评估美国成人样本中血浆反式脂肪酸（TFAs）水平与白细胞端粒长度（TL）之间的关系。
研究对象/方法：本研究使用了国家健康和营养调查（NHANES）数据库。气相色谱法用于分离衍生脂肪酸（四种主要 TFAs [棕榈烯酸（C16:1n-7t）、反式油酸（C18:1n-7t）、反式亚油酸（C18:1n-9t）和亚油酸（C18:2n-6t,9t）]），然后使用负离子化学电离质谱法对其进行定量。数据分析采用多元线性回归，同时考虑了调查设计。
共有 5446 名符合条件的参与者，其中 46.8%（n=2550）为男性。总样本的平均年龄为 47.1 岁，男性和女性分别为 47.8 岁和 46.5 岁（男性与女性差异 p=0.085）。棕榈烯酸和亚油酸的浓度随着端粒长度的增加而降低（p<0.05）。单变量线性回归显示，棕榈烯酸、亚油酸、油酸和反式油酸水平与 TL 呈显著负相关。然而，当模型调整为年龄、性别、种族、教育程度、婚姻状况、亚临床炎症、体重指数和吸烟状况时，只有棕榈烯酸和亚油酸仍然具有显著相关性（p<0.05）。
TFAs 水平，特别是棕榈烯酸和亚油酸，可能与端粒长度呈负相关。未来的研究应该探索这些关联的潜在影响。
