Schwarz Esther I, Engler Anna, Kohler Malcolm
a Sleep Disorders Center and Pulmonary Division , University Hospital of Zurich , Zurich , Switzerland.
b Center for Interdisciplinary Sleep Research , University of Zurich , Zurich , Switzerland.
Expert Rev Respir Med. 2017 Aug;11(8):631-639. doi: 10.1080/17476348.2017.1338950. Epub 2017 Jun 14.
Breath analysis is a novel application that can be used for non-invasive metabolic phenotyping and identification of disease specific breath patterns. Obstructive sleep apnea (OSA) is highly prevalent and has diverse metabolic and cardiovascular consequences, many of them incompletely understood. Areas covered: This review systematically summarizes the current evidence from breath metabolomics using immunoassays of breath condensate, off-line mass spectrometry as well as real-time analysis by electronic sensors and by untargeted mass spectrometry, and discusses the challenges and perspectives of breath analysis in OSA. Expert commentary: Analysis of exhaled breath is an innovative approach that is likely to provide profound insights into the metabolomics of OSA and its consequences and might facilitate diagnosis and therapy monitoring.
呼吸分析是一种可用于非侵入性代谢表型分析和疾病特异性呼吸模式识别的新型应用。阻塞性睡眠呼吸暂停（OSA）非常普遍，会产生多种代谢和心血管方面的后果，其中许多后果尚未完全了解。涵盖领域：本综述系统总结了目前来自呼吸代谢组学的证据，这些证据来自呼吸冷凝物的免疫分析、离线质谱分析以及电子传感器和非靶向质谱的实时分析，并讨论了OSA呼吸分析面临的挑战和前景。专家评论：呼气分析是一种创新方法，可能会为OSA的代谢组学及其后果提供深刻见解，并可能有助于诊断和治疗监测。
