Department of Pulmonology, Semmelweis University, Budapest, Hungary.
Department of Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
Sleep Med Rev. 2016 Jun;27:1-8. doi: 10.1016/j.smrv.2015.07.005. Epub 2015 Aug 5.
Accelerated airway inflammation may play a crucial role in the pathophysiology of obstructive sleep apnoea (OSA); however this phenomenon has been investigated only in a limited number of studies. The analysis of exhaled breath represents a promising, non-invasive tool to evaluate airway inflammation in this context. The knowledge on exhaled biomarkers in OSA has been growing with an emerging number of methodological studies which help to interpret exhaled breath data. This article not only summarises the results of studies on exhaled breath condensate (EBC) biomarkers, exhaled volatile compounds and exhaled monoxides in OSA, but also aims to critically review methodological limitations and provide some guideline for further research.
气道炎症的加速可能在阻塞性睡眠呼吸暂停（OSA）的病理生理学中起着关键作用；然而，这种现象仅在少数研究中进行了研究。呼气分析代表了一种很有前途的、非侵入性的工具，可以在这种情况下评估气道炎症。随着越来越多的方法学研究帮助解释呼气数据，关于 OSA 中呼气生物标志物的知识也在不断增加。本文不仅总结了关于 OSA 中呼出气冷凝物（EBC）生物标志物、呼出气挥发性化合物和呼出气单氧化物的研究结果，还旨在批判性地审查方法学限制，并为进一步研究提供一些指导。
