a Department of Chemistry , Sri Shakthi Institute of Engineering and Technology , Coimbatore 641 062 , Tamil Nadu , India.
b Chemistry Research Lab, Department of Science & Humanities , Karunya University , Coimbatore 641 114 , Tamil Nadu , India.
J Biomol Struct Dyn. 2018 May;36(7):1908-1917. doi: 10.1080/07391102.2017.1337592. Epub 2017 Jun 26.
Flavones are biologically active compounds obtained mainly from plant sources. Pharmaceutically important compounds can be delivered to the physiological target by loading them in carriers like cyclodextrins and magnetic nanoparticles. Herein, the binding of 6-methoxyflavone to β-cyclodextrin and DNA is studied using UV-visible absorption and fluorescence spectroscopy. The loading of 6-methoxyflavone onto a magnetic nanoparticles is employed. β-cyclodextrin encapsulates the 6-methoxyflavone to form an inclusion complex. β-cyclodextrin also used to draw forth 6-methoxyflavone loaded onto a magnetic nanoparticles. The morphology, magnetic property and the crystallite size of the nanoparticles are studied using scanning electron microscopy, vibrating sample magnetometry and X-ray diffraction techniques, respectively. The binding of the drug-loaded magnetic nanoparticles to DNA shows that the compound is accessible to DNA and available mostly on the surface of the nanoparticles despite a modified dextan polymer supposedly encapsulates the flavone.
黄酮类化合物是主要从植物来源中获得的具有生物活性的化合物。可以通过将药物负载到环糊精和磁性纳米粒子等载体中来将药用重要化合物递送到生理靶标。本文使用紫外-可见吸收和荧光光谱法研究了 6-甲氧基黄酮与β-环糊精和 DNA 的结合。将 6-甲氧基黄酮负载到磁性纳米粒子上。β-环糊精将 6-甲氧基黄酮包裹形成包合物。β-环糊精也用于引出负载在磁性纳米粒子上的 6-甲氧基黄酮。使用扫描电子显微镜、振动样品磁强计和 X 射线衍射技术分别研究了纳米粒子的形态、磁性和晶粒尺寸。载药磁性纳米粒子与 DNA 的结合表明，尽管修饰的葡聚糖聚合物据称可以包裹黄酮类化合物，但该化合物仍可与 DNA 结合，并且主要存在于纳米粒子的表面。
