Sudha Natesan, Yousuf Sameena, Israel Enoch V M V, Paulraj Mosae Selvakumar, Dhanaraj Premnath
Department of Chemistry, Karunya University, Coimbatore 641 114, Tamil Nadu, India.
Department of Chemistry, Karunya University, Coimbatore 641 114, Tamil Nadu, India.
Colloids Surf B Biointerfaces. 2016 May 1;141:423-428. doi: 10.1016/j.colsurfb.2016.02.020. Epub 2016 Feb 10.
We report the loading of drugs on aminoethylaminodextran-coated iron oxide nanoparticles, their superparamagnetic behavior, loading of drugs on them, and the β-cyclodextrin-complex formation of the drugs on the surface of the nanoparticles. The magnetic behavior is studied using vibrating sample magnetometry and X-ray photoelectron spectroscopy is used to analyze the elemental composition of drug-loaded nanoparticles. Scanning electron microscopy shows ordered structures of drug-loaded nanoparticles. UV-visible absorption and fluorescence spectroscopy are used to study the binding of the surface-loaded drugs to β-cyclodextrin. All of the drugs form 1:1 host-guest complexes. The iodide ion quenching of fluorescence of free- and iron oxide-attached drugs are compared. The binding strengths of the iron oxide surface-loaded drugs-β-cyclodextrin binding are smaller than those of the free drugs.
我们报道了药物负载于氨乙基氨基葡聚糖包被的氧化铁纳米颗粒上的情况、它们的超顺磁性行为、药物在其上的负载以及纳米颗粒表面药物的β-环糊精复合物形成。使用振动样品磁强计研究磁性行为，并使用X射线光电子能谱分析载药纳米颗粒的元素组成。扫描电子显微镜显示了载药纳米颗粒的有序结构。紫外-可见吸收光谱和荧光光谱用于研究表面负载药物与β-环糊精的结合。所有药物均形成1:1主客体复合物。比较了游离药物和附着于氧化铁的药物的荧光碘离子猝灭情况。氧化铁表面负载药物与β-环糊精的结合强度小于游离药物的结合强度。
