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Plasma HIV-1 RNA viral load rebound among people who inject drugs receiving antiretroviral therapy (ART) in a Canadian setting: an ethno-epidemiological study.加拿大环境下接受抗逆转录病毒疗法(ART)的注射吸毒者中血浆HIV-1 RNA病毒载量反弹:一项种族流行病学研究。
AIDS Res Ther. 2016 Jul 25;13:26. doi: 10.1186/s12981-016-0108-9. eCollection 2016.
2
'Crisis' and 'everyday' initiators: A qualitative study of coercion and agency in the context of methadone maintenance treatment initiation.“危机”与“日常”引发因素:美沙酮维持治疗起始背景下强制与自主性的定性研究
Drug Alcohol Rev. 2017 Mar;36(2):253-260. doi: 10.1111/dar.12411. Epub 2016 Apr 29.
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Public health and international drug policy.公共卫生与国际药物政策。
Lancet. 2016 Apr 2;387(10026):1427-1480. doi: 10.1016/S0140-6736(16)00619-X. Epub 2016 Mar 24.
4
Inability to access addiction treatment predicts injection initiation among street-involved youth in a Canadian setting.无法获得成瘾治疗预示着加拿大街头青少年开始注射吸毒。
Subst Abuse Treat Prev Policy. 2016 Jan 6;11:1. doi: 10.1186/s13011-015-0046-x.
5
Substituting cannabis for prescription drugs, alcohol and other substances among medical cannabis patients: The impact of contextual factors.医用大麻患者用大麻替代处方药、酒精及其他物质:情境因素的影响
Drug Alcohol Rev. 2016 May;35(3):326-33. doi: 10.1111/dar.12323. Epub 2015 Sep 14.
6
Illicit drug use and harms, and related interventions and policy in Canada: A narrative review of select key indicators and developments since 2000.加拿大的非法药物使用与危害、相关干预措施及政策:对2000年以来选定关键指标及发展情况的叙述性综述
Int J Drug Policy. 2016 Jan;27:23-35. doi: 10.1016/j.drugpo.2015.08.007. Epub 2015 Aug 14.
7
The relative risk of fatal poisoning by methadone or buprenorphine within the wider population of England and Wales.在英格兰和威尔士更广泛的人群中,美沙酮或丁丙诺啡导致致命中毒的相对风险。
BMJ Open. 2015 May 29;5(5):e007629. doi: 10.1136/bmjopen-2015-007629.
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A safer alternative: Cannabis substitution as harm reduction.一种更安全的替代方案:大麻替代作为减少危害的措施。
Drug Alcohol Rev. 2015 Nov;34(6):654-9. doi: 10.1111/dar.12275. Epub 2015 Apr 28.
9
Negotiating structural vulnerability following regulatory changes to a provincial methadone program in Vancouver, Canada: A qualitative study.加拿大温哥华省级美沙酮项目监管变更后应对结构脆弱性的探讨:一项定性研究
Soc Sci Med. 2015 May;133:168-76. doi: 10.1016/j.socscimed.2015.04.008. Epub 2015 Apr 7.
10
The Risk Environment of Heroin Use Initiation: Young Women, Intimate Partners, and "Drug Relationships".海洛因使用起始的风险环境:年轻女性、亲密伴侣与“毒品关系”
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影响加拿大温哥华注射毒品的边缘化青年注射中断期的社会结构因素:一项种族流行病学研究。

Social-structural factors influencing periods of injection cessation among marginalized youth who inject drugs in Vancouver, Canada: an ethno-epidemiological study.

作者信息

Boyd Jade, Fast Danya, Hobbins Megan, McNeil Ryan, Small Will

机构信息

British Columbia Centre on Substance Use, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

出版信息

Harm Reduct J. 2017 Jun 5;14(1):31. doi: 10.1186/s12954-017-0159-9.

DOI:10.1186/s12954-017-0159-9
PMID:28583136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5460503/
Abstract

BACKGROUND

Injection drug use is associated with HIV and hepatitis C transmission, overdose, and other preventable harms. These harms are heightened for structurally vulnerable injection drug-using populations, as their social conditions pose barriers to safer injecting. Previous research on injection cessation has largely focused on adult drug-using populations. Little qualitative work has examined the social, structural, and environmental factors that shape periods of injection cessation among youth and young adults. Such research is essential to understanding how we can best reduce harms among this vulnerable population as they move in and out of periods of injection cessation.

METHODS

We conducted 22 semi-structured, qualitative interviews with street-involved young people who use drugs (SY), focused on characterizing their transitions into periods of injection cessation and perceived barriers to injection cessation. Adopting an ethno-epidemiological approach, participants who had experienced at least 6 months of injection cessation were purposively recruited from an ongoing prospective cohort study of SY in Vancouver, Canada to participate in qualitative interviews. Qualitative interview findings were triangulated with the findings of a longitudinal program of ethnographic research with SY in this setting. This ethno-epidemiological approach allowed for a more robust exploration of contextual factors surrounding drug use patterns than would be possible through traditional epidemiological methods alone.

RESULTS

Findings indicate that periods of injection cessation were influenced by access to harm reduction-informed youth-focused services, transitions in route of administration (e.g., from injecting methamphetamine to the smoking of methamphetamine), and the provision of housing and social supports (e.g., from friends, family, and care providers). Conversely, participants indicated that inadequate social supports and, for some, abstinence-focused treatment methods (e.g., 12-step programs), impeded efforts to cease injecting.

CONCLUSIONS

To reduce harms, it is imperative to reorient attention toward the social, structural, and spatial contexts that surround injection drug use and shape periods of injection cessation for SY. There is an urgent need for more comprehensive youth-focused services for those engaged in injection drug use, and further study of innovative means of engaging youth.

摘要

背景

注射吸毒与艾滋病毒和丙型肝炎传播、药物过量及其他可预防的危害相关。对于在结构上处于弱势的注射吸毒人群而言,这些危害更为严重,因为他们的社会状况给更安全的注射行为带来了障碍。此前关于停止注射的研究主要集中在成年吸毒人群。很少有定性研究探讨影响青少年和青年停止注射阶段的社会、结构和环境因素。此类研究对于理解如何在这一弱势群体进出停止注射阶段时,最大程度地减少危害至关重要。

方法

我们对涉足街头的吸毒青年(SY)进行了22次半结构化定性访谈,重点是描述他们进入停止注射阶段的转变过程以及停止注射所感知到的障碍。采用民族流行病学方法,从加拿大温哥华一项正在进行的SY前瞻性队列研究中,有目的地招募了至少经历过6个月停止注射的参与者,以参与定性访谈。定性访谈结果与在此背景下对SY进行的民族志研究纵向项目结果进行了三角互证。这种民族流行病学方法比仅通过传统流行病学方法更能深入探究围绕吸毒模式的背景因素。

结果

研究结果表明,停止注射阶段受到以下因素影响:获得以减少危害为导向的针对青年的服务;给药途径的转变(例如,从注射甲基苯丙胺转变为吸食甲基苯丙胺);住房和社会支持的提供(例如,来自朋友、家人和护理提供者)。相反,参与者表示社会支持不足,而且对一些人来说,以禁欲为重点的治疗方法(例如12步戒毒计划)阻碍了停止注射的努力。

结论

为减少危害,必须将注意力重新转向围绕注射吸毒以及影响SY停止注射阶段的社会、结构和空间背景。迫切需要为注射吸毒者提供更全面的以青年为重点的服务,并进一步研究吸引青年的创新方式。