Dalich G M, Larson R E
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;80(1):115-22. doi: 10.1016/0742-8413(85)90141-0.
Chlorobenzene (CB) was less hepatotoxic to trout than to rats. This difference could not be totally accounted for by reduced absorption in the trout and CB was metabolized in the trout. Glutathione concentrations in trout livers were 1/3 of those of the rat and prior depletion of the tripeptide led to irreversible binding of CB to trout liver protein equivalent to that of rats suffering extensive necrosis. No consistent correlation between glutathione content or protein binding and liver damage was seen in either species.
氯苯（CB）对鳟鱼的肝脏毒性比对大鼠的要小。鳟鱼对氯苯的吸收减少并不能完全解释这种差异，而且氯苯在鳟鱼体内会被代谢。鳟鱼肝脏中的谷胱甘肽浓度是大鼠的三分之一，预先耗尽这种三肽会导致氯苯与鳟鱼肝脏蛋白质发生不可逆结合，这与遭受广泛坏死的大鼠情况相当。在这两个物种中，谷胱甘肽含量或蛋白质结合与肝脏损伤之间均未发现一致的相关性。
