Pang K S
J Pharmacokinet Biopharm. 1981 Aug;9(4):477-87. doi: 10.1007/BF01060890.
A model comprised of four compartments, a central and liver compartment for a drug, and a central and liver compartment for a metabolite, is presented to describe the interrelationships between the area under the curve of the metabolite and physiological parameters after intravenous and intraportal administration of the drug. The model includes renal and hepatic eliminatory mechanisms for both drug and metabolite as long as the metabolite is formed only by the liver. It is found that when competing renal eliminatory pathways exist for a drug, the area under the curve for the metabolite will change according to the route of drug administration. Also, the fractional rate of metabolism of a drug to form the metabolite will be underestimated by the normal use of the ratio areas under the curve of the metabolite. Other properties of the model are also discussed.
提出了一个由四个隔室组成的模型，一个用于药物的中央隔室和肝脏隔室，以及一个用于代谢物的中央隔室和肝脏隔室，以描述静脉内和门静脉内给药后代谢物曲线下面积与生理参数之间的相互关系。只要代谢物仅由肝脏形成，该模型就包括药物和代谢物的肾脏和肝脏消除机制。研究发现，当药物存在竞争性肾脏消除途径时，代谢物的曲线下面积将根据药物给药途径而变化。此外，通过正常使用代谢物曲线下面积的比值，将低估药物形成代谢物的代谢分数率。还讨论了该模型的其他特性。
