肿瘤生长过程中造血干细胞的增殖与分化
[Proliferation and differentiation of hematopoietic stem cells during tumor growth].
作者信息
Batyrbekov A A, Aripova T U, Islamova N T
出版信息
Eksp Onkol. 1985;7(1):46-8.
PMID:2858388
Abstract
The influence of transplantable tumour on migration, proliferation and differentiation of haemopoietic stem cells was studied. It is shown that in the initial period of tumour development the migration and proliferation of stem cells intensify. In the final stage of the tumour growth the quantity of haemopoietic stem cells decreases considerably in the bone marrow, spleen, and peripheral blood. It is established that during the tumour growth the differentiation of stem cells from the spleen changed towards erythropoiesis.
摘要
研究了可移植肿瘤对造血干细胞迁移、增殖和分化的影响。结果表明，在肿瘤发展初期，干细胞的迁移和增殖增强。在肿瘤生长的最后阶段，骨髓、脾脏和外周血中的造血干细胞数量显著减少。已确定在肿瘤生长过程中，脾脏干细胞的分化向红细胞生成方向转变。
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