莫达非尼治疗精神分裂症：值得冒这个风险吗？
Modafinil in schizophrenia: is the risk worth taking?
作者信息
Neto Daniel, Spínola Carla, Gago Joaquim
机构信息
Departamento de Psiquiatria e Saúde Mental, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal.
Departamento de Saúde Mental, NOVA Medical School - Faculdade de Ciências Médicas, Lisboa, Portugal.
出版信息
BMJ Case Rep. 2017 Jun 5;2017:bcr-2017-219218. doi: 10.1136/bcr-2017-219218.
Abstract
Schizophrenia is a severe mental disorder characterised by positive and negative symptoms. Negative symptoms are difficult to treat and there is no specific treatment. In small trials, modafinil has been studied in association with antipsychotic treatment. We present three cases of its use; two have developed positive symptoms and one developed renal impairment. Further studies are needed to assess its usefulness in schizophrenia and safety in this group of patients.
摘要
精神分裂症是一种以阳性和阴性症状为特征的严重精神障碍。阴性症状难以治疗且没有特效疗法。在小型试验中，已对莫达非尼与抗精神病药物联合治疗进行了研究。我们介绍了三例使用该药物的病例；其中两例出现了阳性症状，一例出现了肾功能损害。需要进一步研究以评估其在精神分裂症治疗中的有效性以及在这类患者中的安全性。
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