Aytaş Özgür, Dilek Yalvaç Hayriye
Clinic of Psychiatry, Malatya State Hospital, Malatya, Turkey.
Clinic of Psychiatry, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.
Noro Psikiyatr Ars. 2015 Mar;52(1):99-101. doi: 10.5152/npa.2015.7160. Epub 2015 Mar 1.
Modafinil is used in the treatment of excessive day time sleepiness associated with several clinical conditions. It can also be used for affective stimulation for working late and/or concentrating for a long time. The reported cases of psychosis associated with modafinil use in the literature, have medical or psychiatric diorders. There is only one reported case without medical or psychiatric disorder but developed modafinil related psychosis, which is a case under simulated shift work in laboratory conditions. The cases in the literature are reported to develop mania or psychosis with 200-400 mg/day or higher doses. The case reported in this manuscript develop psychosis with 100 mg/day dosage. This case has no previous psychiatric and medical disorder history and not being on a shift work. The aim of modafinil use in this case was reported as increasing the concentration and performance while studying. Modafinil using patients must be psychiatrically monitored for its potential psychotic effect even in previously healthy individuals and low doses.
莫达非尼用于治疗与多种临床病症相关的日间过度嗜睡。它也可用于在工作到很晚时或长时间集中注意力时的情感刺激。文献中报道的与使用莫达非尼相关的精神病病例，患者都有医学或精神疾病。仅有一例报道的病例没有医学或精神疾病，但却出现了与莫达非尼相关的精神病，这是一例在实验室条件下模拟轮班工作的病例。文献中的病例据报道在每日服用200 - 400毫克或更高剂量时会出现躁狂或精神病。本手稿中报道的病例在每日服用100毫克剂量时出现了精神病。该病例既往无精神病史和医学疾病史，也未从事轮班工作。该病例中使用莫达非尼的目的据报道是在学习时提高注意力和表现。即使是既往健康的个体且使用低剂量莫达非尼，也必须对使用莫达非尼的患者进行精神病学监测，以防其产生潜在的精神病效应。
