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本文引用的文献

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Higher rates of neuropsychiatric adverse events leading to dolutegravir discontinuation in women and older patients.女性和老年患者中导致多替拉韦停药的神经精神不良事件发生率更高。
HIV Med. 2017 Jan;18(1):56-63. doi: 10.1111/hiv.12468. Epub 2016 Nov 10.
2
Safety and Tolerability: Current Challenges to Antiretroviral Therapy for the Long-Term Management of HIV Infection.安全性与耐受性：长期管理HIV感染的抗逆转录病毒疗法面临的当前挑战
AIDS Rev. 2016 Jul-Sep;18(3):127-137.
3
Association of circulating cytochrome c with clinical manifestations of antiretroviral-induced toxicity.循环细胞色素c与抗逆转录病毒药物诱导毒性的临床表现之间的关联。
Mitochondrion. 2015 Jan;20:71-4. doi: 10.1016/j.mito.2014.11.004. Epub 2014 Nov 28.
4
Short communication: Apoptosis pathways in HIV-1-infected patients before and after highly active antiretroviral therapy: relevance to immune recovery.简短通讯：高效抗逆转录病毒治疗前后HIV-1感染患者的凋亡途径：与免疫恢复的相关性
AIDS Res Hum Retroviruses. 2015 Feb;31(2):208-16. doi: 10.1089/aid.2014.0038. Epub 2014 Nov 11.
5
Apoptosis-associated genes related to photodynamic therapy in breast carcinomas.乳腺癌光动力治疗相关凋亡相关基因。
Lasers Med Sci. 2014 Jul;29(4):1429-36. doi: 10.1007/s10103-014-1547-y. Epub 2014 Feb 27.
6
Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study.抗逆转录病毒治疗暴露与基线肾功能正常的 HIV 阳性人群肾功能损害的相关性：D:A:D 研究。
J Infect Dis. 2013 May 1;207(9):1359-69. doi: 10.1093/infdis/jit043. Epub 2013 Feb 4.
7
Interruption or deferral of antiretroviral therapy reduces markers of bone turnover compared with continuous therapy: The SMART body composition substudy.与连续治疗相比，中断或延迟抗逆转录病毒治疗可降低骨转换标志物：SMART 身体成分子研究。
J Bone Miner Res. 2013 Jun;28(6):1264-74. doi: 10.1002/jbmr.1861.
8
Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition.抗 HIV 药物对线粒体的干扰：超越 Pol-γ 抑制的机制。
Trends Pharmacol Sci. 2011 Dec;32(12):715-25. doi: 10.1016/j.tips.2011.07.007. Epub 2011 Sep 6.
9
Apoptosis: a clinically useful measure of antiretroviral drug toxicity?细胞凋亡：抗逆转录病毒药物毒性的一种有临床应用价值的衡量指标？
Expert Opin Drug Metab Toxicol. 2009 Dec;5(12):1543-53. doi: 10.1517/17425250903282781.
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Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment.核苷、非核苷及蛋白酶抑制剂简化治疗方案用于初始HIV治疗的随机试验中的代谢结果
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抗逆转录病毒治疗相关线粒体毒性的 HIV 感染者外周血单个核细胞中凋亡途径基因的上调。

Upregulation of Apoptosis Pathway Genes in Peripheral Blood Mononuclear Cells of HIV-Infected Individuals with Antiretroviral Therapy-Associated Mitochondrial Toxicity.

机构信息

Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.

Ragon Institute and Harvard Medical School, Cambridge, Massachusetts, USA.

出版信息

Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00522-17. Print 2017 Aug.

DOI:10.1128/AAC.00522-17
PMID:28584150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5527626/
Abstract

A case-control study of the effect of antiretroviral therapy (ART) on apoptosis pathway genes comprising 16 cases (HIV infected with mitochondrial toxicity) and 16 controls (HIV uninfected) was conducted. A total of 26 of 84 genes of the apoptosis pathway were differentially expressed. Two of the upregulated genes, DFFA and TNFRSF1A, classified 75% of study participants correctly as either a case or control. Thus, apoptosis may be in the causal pathway of ART-associated mitochondrial toxicity. These two genes could be markers for detecting and monitoring ART-induced mitochondrial toxicity.

摘要

进行了一项包含 16 例病例（感染 HIV 合并线粒体毒性）和 16 例对照（未感染 HIV）的抗逆转录病毒治疗（ART）对凋亡途径基因影响的病例对照研究。共有 84 个凋亡途径基因中的 26 个基因表达存在差异。两个上调基因 DFFA 和 TNFRSF1A 可正确分类 75%的研究参与者为病例或对照。因此，凋亡可能处于 ART 相关性线粒体毒性的因果途径中。这两个基因可能是检测和监测 ART 诱导的线粒体毒性的标志物。