Suppr超能文献

骨转移:概述

Bone Metastases: An Overview.

作者信息

Macedo Filipa, Ladeira Katia, Pinho Filipa, Saraiva Nadine, Bonito Nuno, Pinto Luisa, Goncalves Francisco

机构信息

Medical Oncology Department, Portuguese Oncology Institute, Coimbra, Portugal.

Internal Medicine Department, Braga Hospital, Braga, Portugal.

出版信息

Oncol Rev. 2017 May 9;11(1):321. doi: 10.4081/oncol.2017.321. eCollection 2017 Mar 3.

Abstract

Bone is a frequent site of metastases and typically indicates a short-term prognosis in cancer patients. Once cancer has spread to the bones it can rarely be cured, but often it can still be treated to slow its growth. The majority of skeletal metastases are due to breast and prostate cancer. Bone metastasis is actually much more common than primary bone cancers, especially in adults. The diagnosis is based on signs, symptoms and imaging. New classes of drugs and new interventions are given a better quality of life to these patients and improved the expectancy of life. It is necessary a multidisciplinary approach to treat patients with bone metastasis. In this paper we review the types, clinical approach and treatment of bone metastases.

摘要

骨骼是转移瘤的常见部位,通常预示着癌症患者的短期预后。一旦癌症扩散至骨骼,很少能够治愈,但通常仍可进行治疗以减缓其生长。大多数骨转移瘤源于乳腺癌和前列腺癌。骨转移瘤实际上比原发性骨癌更为常见,尤其是在成年人中。诊断基于体征、症状和影像学检查。新型药物和新的干预措施提高了这些患者的生活质量,并延长了预期寿命。治疗骨转移瘤患者需要多学科方法。在本文中,我们综述了骨转移瘤的类型、临床方法和治疗。

相似文献

1
Bone Metastases: An Overview.
Oncol Rev. 2017 May 9;11(1):321. doi: 10.4081/oncol.2017.321. eCollection 2017 Mar 3.
2
Bisphosphonates and other bone agents for breast cancer.
Cochrane Database Syst Rev. 2012 Feb 15(2):CD003474. doi: 10.1002/14651858.CD003474.pub3.
3
Bisphosphonates for breast cancer.
Cochrane Database Syst Rev. 2005 Jul 20(3):CD003474. doi: 10.1002/14651858.CD003474.pub2.
5
More advantages in detecting bone and soft tissue metastases from prostate cancer using F-PSMA PET/CT.
Hell J Nucl Med. 2019 Jan-Apr;22(1):6-9. doi: 10.1967/s002449910952. Epub 2019 Mar 7.
6
Bisphosphonates for breast cancer.
Cochrane Database Syst Rev. 2002(1):CD003474. doi: 10.1002/14651858.CD003474.
8
Denosumab for the prevention of skeletal-related events in patients with bone metastasis from solid tumor.
Pharmacotherapy. 2012 Mar;32(3):274-84. doi: 10.1002/j.1875-9114.2011.01092.x. Epub 2012 Feb 13.
10
Progress in the treatment of bone metastases in cancer patients.
Expert Opin Investig Drugs. 2012 Jun;21(6):785-95. doi: 10.1517/13543784.2012.679928. Epub 2012 Apr 16.

引用本文的文献

3
Proximal Femoral Replacement or Revision Stem Hemiarthroplasty for Metastatic Disease of the Proximal Femur-Is There Any Notable Difference?
J Am Acad Orthop Surg Glob Res Rev. 2025 Jul 29;9(8). doi: 10.5435/JAAOSGlobal-D-24-00243. eCollection 2025 Aug 1.
4
Epidemiology of bone metastasis in France between 2009 and 2018.
JBMR Plus. 2025 May 6;9(8):ziaf081. doi: 10.1093/jbmrpl/ziaf081. eCollection 2025 Aug.
6
Merkel Cell Carcinoma: An Updated Review Focused on Bone and Bone Marrow Metastases.
Cancers (Basel). 2025 Jul 6;17(13):2253. doi: 10.3390/cancers17132253.
7
Timely integration of palliative care into oncology care for patients with bone metastases at the radiotherapy department: A pilot study on acceptability and feasibility.
Tech Innov Patient Support Radiat Oncol. 2025 Jun 10;35:100317. doi: 10.1016/j.tipsro.2025.100317. eCollection 2025 Sep.

本文引用的文献

1
Bone health in cancer patients: ESMO Clinical Practice Guidelines.
Ann Oncol. 2014 Sep;25 Suppl 3:iii124-37. doi: 10.1093/annonc/mdu103. Epub 2014 Apr 29.
2
Alpha emitter radium-223 and survival in metastatic prostate cancer.
N Engl J Med. 2013 Jul 18;369(3):213-23. doi: 10.1056/NEJMoa1213755.
3
A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases.
Clin Cancer Res. 2013 Jun 1;19(11):3088-94. doi: 10.1158/1078-0432.CCR-13-0319. Epub 2013 Apr 3.
4
Percutaneous image-guided cryoablation of painful metastases involving bone: multicenter trial.
Cancer. 2013 Mar 1;119(5):1033-41. doi: 10.1002/cncr.27793. Epub 2012 Oct 12.
5
[Effect of bisphosphonates on anticancer activity in prostate cancer cells].
Yakugaku Zasshi. 2012;132(9):1025-30. doi: 10.1248/yakushi.132.1025.
6
Denosumab, a RANK ligand inhibitor, for the management of bone loss in cancer patients.
Clin Interv Aging. 2012;7:331-8. doi: 10.2147/CIA.S14566. Epub 2012 Sep 3.
7
Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid.
Biochim Biophys Acta. 2012 Dec;1820(12):1926-39. doi: 10.1016/j.bbagen.2012.07.013. Epub 2012 Aug 3.
8
Zoledronic acid as an adjuvant therapy in patients with breast cancer: a systematic review and meta-analysis.
PLoS One. 2012;7(7):e40783. doi: 10.1371/journal.pone.0040783. Epub 2012 Jul 26.
10
The role of stereotactic radiosurgery in metastasis to the spine.
J Korean Neurosurg Soc. 2012 Jan;51(1):1-7. doi: 10.3340/jkns.2012.51.1.1. Epub 2012 Jan 31.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验