Ikuoyogie Kingsley, Ogefere Helen Oroboghae, Omoregie Richard
Divine Favour Medical Laboratories, Benin City, Nigeria.
Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria.
Oman Med J. 2017 May;32(3):207-213. doi: 10.5001/omj.2017.39.
Because of lack of data on the prevalence of sulfadoxine antibody, this study was conducted to determine the prevalence of sulfadoxine antibodies and its possible risk factors.
Blood specimens were collected from 500 patients undergoing treatment for malaria at Central Hospital, Benin City, Nigeria. A structured questionnaire was used to collect information and sociodemographic data. Sulfadoxine antibodies were detected by drug absorption (DAT) and immune complex (IMC) methods. ABO, rhesus blood group, and hemoglobin (Hb) phenotype were determined by using standard technique.
DAT method had a significantly higher rate of detecting sulfadoxine antibodies compared to IMC method ( 0.019). Age, gender, and level of education did not affect the prevalence of sulfadoxine antibodies ( > 0.050). Patients that were an artisan ( < 0.001), married ( 0.025), living in a two-room apartment ( 0.003), had history of drug reaction, consumed antimalarial drug (maloxine), and consumed sulfadoxine-containing drug within the last month ( < 0.001 each), and significantly affected the prevalence of sulfadoxine antibodies. Individuals with Hb phenotype AA had significantly higher prevalence of sulfadoxine antibodies ( < 0.001), and presence of rhesus D antigen was associated with sulfadoxine antibodies.
An overall prevalence of 22.0% among the tested individuals had sulfadoxine antibodies. Prudent use of sulfadoxine containing drugs is advocated.
由于缺乏关于磺胺多辛抗体患病率的数据，本研究旨在确定磺胺多辛抗体的患病率及其可能的危险因素。
从尼日利亚贝宁市中心医院500名正在接受疟疾治疗的患者中采集血样。使用结构化问卷收集信息和社会人口统计学数据。通过药物吸收（DAT）和免疫复合物（IMC）方法检测磺胺多辛抗体。采用标准技术确定ABO血型、恒河猴血型和血红蛋白（Hb）表型。
与IMC方法相比，DAT方法检测磺胺多辛抗体的比率显著更高（0.019）。年龄、性别和教育程度不影响磺胺多辛抗体的患病率（>0.050）。职业为工匠的患者（<0.001）、已婚患者（0.025）、居住在两居室公寓的患者（0.003）、有药物反应史的患者、服用抗疟药（马洛辛）的患者以及在过去一个月内服用含磺胺多辛药物的患者（每项均<0.001），均显著影响磺胺多辛抗体的患病率。Hb表型为AA的个体磺胺多辛抗体患病率显著更高（<0.001），恒河猴D抗原的存在与磺胺多辛抗体相关。
在受试个体中，磺胺多辛抗体的总体患病率为22.0%。提倡谨慎使用含磺胺多辛的药物。
