连接蛋白43：在皮肤中的关键作用。
Connexin 43: Key roles in the skin.
作者信息
Zhang Xiao-Fei, Cui Xiaofeng
机构信息
Department of Biological Sciences and Biotechnology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei 430070, P.R. China.
出版信息
Biomed Rep. 2017 Jun;6(6):605-611. doi: 10.3892/br.2017.903. Epub 2017 May 3.
Gap junctions are tightly packed intercellular channels that serve a common purpose of allowing the intercellular exchange of small metabolites, second messengers and electrical signals. Connexins (Cxs) are gap junction proteins. Currently, 20 and 21 members of Cxs have been characterized in mice and humans, respectively. Connexin 43 (Cx43) is the most ubiquitously expressed type of Cx in the skin. It is produced by various different types of skin cell, such as keratinocytes, fibroblasts, endothelial and basal cells, melanocytes and dermal papilla cells. At present, more evidence indicates that Cx43 has an important role in skin repair and skin tumor development, as well as in skin cell invasion and metastasis. In this review, current knowledge regarding the regulation and function of Cx43 is summarized and the therapeutic potential of regulating Cx43 activity is discussed.
缝隙连接是紧密排列的细胞间通道，其共同作用是允许小代谢物、第二信使和电信号进行细胞间交换。连接蛋白（Cxs）是构成缝隙连接的蛋白质。目前，已分别在小鼠和人类中鉴定出20种和21种Cxs成员。连接蛋白43（Cx43）是皮肤中表达最广泛的Cx类型。它由多种不同类型的皮肤细胞产生，如角质形成细胞、成纤维细胞、内皮细胞和基底细胞、黑素细胞和真皮乳头细胞。目前，越来越多的证据表明，Cx43在皮肤修复、皮肤肿瘤发生以及皮肤细胞侵袭和转移中发挥着重要作用。在这篇综述中，总结了关于Cx43调控和功能的现有知识，并讨论了调节Cx43活性的治疗潜力。
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