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连接蛋白与血管生成：功能方面、发病机制和新兴疗法（综述）。

Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review).

机构信息

Department of Cardio‑Thoracic Surgery, Shenzhen University General Hospital, Shenzhen, Guangdong 518055, P.R. China.

出版信息

Int J Mol Med. 2022 Aug;50(2). doi: 10.3892/ijmm.2022.5166. Epub 2022 Jun 28.

DOI:10.3892/ijmm.2022.5166
PMID:35762312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9256078/
Abstract

Connexins (Cxs) play key roles in cellular communication. By facilitating metabolite exchange or interfering with distinct signaling pathways, Cxs affect cell homeostasis, proliferation, and differentiation. Variations in the activity and expression of Cxs have been linked to numerous clinical conditions including carcinomas, cardiac disorders, and wound healing. Recent discoveries on the association between Cxs and angiogenesis have sparked interest in Cx‑mediated angiogenesis due to its essential functions in tissue formation, wound repair, tumor growth, and metastasis. It is now widely recognized that understanding the association between Cxs and angiogenesis may aid in the development of new targeted therapies for angiogenic diseases. The aim of the present review was to provide a comprehensive overview of Cxs and Cx‑mediated angiogenesis, with a focus on therapeutic implications.

摘要

间隙连接蛋白（Connexins，Cxs）在细胞通讯中发挥着关键作用。通过促进代谢物交换或干扰不同的信号通路，Cxs 影响细胞的动态平衡、增殖和分化。Cxs 的活性和表达的变化与许多临床病症有关，包括癌、心脏疾病和伤口愈合。最近发现 Cxs 与血管生成之间的关联引起了人们对 Cx 介导的血管生成的兴趣，因为它在组织形成、伤口修复、肿瘤生长和转移中具有重要功能。现在已经广泛认识到，了解 Cxs 与血管生成之间的关联可能有助于为血管生成性疾病开发新的靶向治疗方法。本综述的目的是全面概述 Cxs 和 Cx 介导的血管生成，并重点介绍其治疗意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/d14a3ca5790e/IJMM-50-2-05166-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/a9252f3259ad/IJMM-50-2-05166-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/5356b9136638/IJMM-50-2-05166-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/fc3ae15d4903/IJMM-50-2-05166-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/d2b1c349be8d/IJMM-50-2-05166-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/d14a3ca5790e/IJMM-50-2-05166-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/a9252f3259ad/IJMM-50-2-05166-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/5356b9136638/IJMM-50-2-05166-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/fc3ae15d4903/IJMM-50-2-05166-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/d2b1c349be8d/IJMM-50-2-05166-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/9256078/d14a3ca5790e/IJMM-50-2-05166-g04.jpg

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