Radovanović Spurnić Aleksandra, Brmbolić Branko, Stojšić Zorica, Pekmezović Tatijana, Bukumirić Zoran, Korać Miloš, Salemović Dubravka, Pešić-Pavlović Ivana, Stevanović Goran, Milošević Ivana, Jevtović Djordje
Hospital for Infectious and Tropical Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
PeerJ. 2017 May 30;5:e3392. doi: 10.7717/peerj.3392. eCollection 2017.
is one of the most common human bacterial infections with prevalence rates between 10-80% depending upon geographical location, age and socioeconomic status. is commonly found in patients complaining of dyspepsia and is a common cause of gastritis. During the course of their infection, people living with HIV (PLHIV) often have a variety of gastrointestinal symptoms including dyspepsia and while previous studies have reported HIV and co-infection, there has been little data clarifying the factors influencing this. The aim of this case-control study was to document the prevalence of co-infection within the HIV community as well as to describe endoscopic findings, gastritis topography and histology, along with patient demographic characteristics across three different periods of time during which antiretroviral therapy (ART) has evolved, from pre- highly active antiretroviral therapy (HAART) to early and modern HAART eras. These data were compared to well-matched HIV negative controls. Two hundred and twelve PLHIV were compared with 1,617 controls who underwent their first esophagogastroduodenoscopy (EGD) to investigate dyspepsia. The prevalence of co-infection among PLHIV was significantly higher in the early (30.2%) and modern HAART period (34.4%) compared with those with coinfection from the pre-HAART period (18.2%). The higher rates seen in patients from the HAART eras were similar to those observed among HIV negative controls (38.5%). This prevalence increase among co-infected patients was in contrast to the fall in prevalence observed among controls, from 60.7% in the early period to 52.9% in the second observed period. The three PLHIV co-infected subgroups differed regarding gastritis topography, morphology and pathology. This study suggests that ART has an important impact on the endoscopic and histological features of gastritis among HIV/ co-infected individuals, raising the possibility that -induced gastritis could be an immune restoration disease.
是最常见的人类细菌感染之一，患病率在10%至80%之间，具体取决于地理位置、年龄和社会经济地位。常见于主诉消化不良的患者中，是胃炎的常见病因。在感染过程中，艾滋病毒感染者（PLHIV）经常出现各种胃肠道症状，包括消化不良，虽然先前的研究报告了艾滋病毒与[具体细菌名称]的合并感染，但几乎没有数据阐明影响这种情况的因素。本病例对照研究的目的是记录艾滋病毒感染者群体中[具体细菌名称]合并感染的患病率，描述内镜检查结果、胃炎的部位、形态学和组织学，以及在抗逆转录病毒疗法（ART）发展的三个不同时期（从高效抗逆转录病毒疗法[HAART]之前到早期和现代HAART时代）患者的人口统计学特征。将这些数据与匹配良好的艾滋病毒阴性对照进行比较。212名PLHIV与1617名因消化不良接受首次食管胃十二指肠镜检查（EGD）的对照进行比较。与HAART之前时期合并感染的患者（18.2%）相比，PLHIV中[具体细菌名称]合并感染的患病率在早期（30.2%）和现代HAART时期（34.4%）显著更高。HAART时代患者中较高的患病率与艾滋病毒阴性对照中观察到的患病率（38.5%）相似。合并感染患者中这种患病率的增加与对照中观察到的患病率下降形成对比，对照中患病率从早期的60.7%降至第二个观察期的52.9%。三个PLHIV合并感染亚组在胃炎的部位、形态和病理方面存在差异。本研究表明，ART对艾滋病毒/[具体细菌名称]合并感染个体的胃炎内镜和组织学特征有重要影响，增加了[具体细菌名称]诱导的胃炎可能是一种免疫恢复疾病的可能性。
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