Clinical Research Unity - Department of Internal Medicine - Federal University of Ceará, Fortaleza, Ceará, Brazil.
BMC Gastroenterol. 2011 Feb 19;11:13. doi: 10.1186/1471-230X-11-13.
This study conducted in Northeastern Brazil, evaluated the prevalence of H. pylori infection and the presence of gastritis in HIV-infected patients.
There were included 113 HIV-positive and 141 age-matched HIV-negative patients, who underwent upper gastrointestinal endoscopy for dyspeptic symptoms. H. pylori status was evaluated by urease test and histology.
The prevalence of H. pylori infection was significantly lower (p < 0.001) in HIV-infected (37.2%) than in uninfected (75.2%) patients. There were no significant differences between H. pylori status and gender, age, HIV viral load, antiretroviral therapy and the use of antibiotics. A lower prevalence of H. pylori was observed among patients with T CD4 cell count below 200/mm3; however, it was not significant. Chronic active antral gastritis was observed in 87.6% of the HIV-infected patients and in 780.4% of the control group (p = 0.11). H. pylori infection was significantly associated with chronic active gastritis in the antrum in both groups, but it was not associated with corpus chronic active gastritis in the HIV-infected patients.
We demonstrated that the prevalence of H. pylori was significantly lower in HIV-positive patients compared with HIV-negative ones. However, corpus gastritis was frequently observed in the HIV-positive patients, pointing to different mechanisms than H. pylori infection in the genesis of the lesion.
本研究在巴西东北部进行，评估了 HIV 感染患者中幽门螺杆菌感染和胃炎的患病率。
共纳入 113 例 HIV 阳性和 141 例年龄匹配的 HIV 阴性患者，这些患者因消化不良症状接受了上消化道内镜检查。通过尿素酶试验和组织学评估幽门螺杆菌状态。
HIV 感染患者（37.2%）的幽门螺杆菌感染患病率明显低于未感染患者（75.2%）（p<0.001）。幽门螺杆菌状态与性别、年龄、HIV 病毒载量、抗逆转录病毒治疗和抗生素使用无关。T 细胞 CD4 计数低于 200/mm3 的患者中，幽门螺杆菌的患病率较低，但无统计学意义。87.6%的 HIV 感染患者和 780.4%的对照组患者观察到慢性活动性胃炎（p=0.11）。在两组中，幽门螺杆菌感染均与胃窦部慢性活动性胃炎显著相关，但与 HIV 感染患者胃体部慢性活动性胃炎无关。
与 HIV 阴性患者相比，我们发现 HIV 阳性患者中幽门螺杆菌的患病率明显较低。然而，HIV 阳性患者中常观察到胃体炎，这表明在病变的发生中存在不同于幽门螺杆菌感染的机制。
