Wang Yicun, Wang Li
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, China.
Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University, 5268 Renmin Street, Changchun, 130042, China.
Methods Mol Biol. 2017;1625:225-235. doi: 10.1007/978-1-4939-7104-6_15.
Phage-displayed antigenic epitope is able to induce both humoral and cell-mediated immune responses, which could be used as an delivery system to design vaccines without compromising safety and tolerability. Here, we describe the vaccination with phage-displayed antigenic epitope (M13 phage-displayed SLAQVKYTSASSI) against Candida albicans infection in BALB/c mice by this method.
噬菌体展示的抗原表位能够诱导体液免疫和细胞介导的免疫反应，其可作为一种递送系统来设计疫苗，且不影响安全性和耐受性。在此，我们描述了通过这种方法用噬菌体展示的抗原表位（M13噬菌体展示的SLAQVKYTSASSI）对BALB/c小鼠进行疫苗接种以抵抗白色念珠菌感染。
