Richardson M L, Bowron J M
J Pharm Pharmacol. 1985 Jan;37(1):1-12. doi: 10.1111/j.2042-7158.1985.tb04922.x.
Increased demands for potable water, especially where supplies are drawn from lowland rivers has necessitated a greater degree of water re-use. As water undertakings have a duty to maintain the wholesome quality of potable water supplies, increasing concern is being expressed over the presence of organic micro-contaminants (contaminants found at microgram litre-1 concentrations). This study outlines some of the problems encountered in assessing the risk from pharmaceutical chemicals which might enter the water cycle from domestic and industrial sources. Analytical chemistry was of value for only a few of the 200 compounds studied. However, much useful information was derived from the human metabolic routes of the drugs and is collated in Appendix I. Biodegradation studies and other ecotoxicity/environmental toxicology data may be required to a greater extent in the future. Particular consideration is given to vulnerable sections of the population.
对饮用水的需求不断增加，尤其是在从低地河流取水的地方，这使得更大程度的水再利用成为必要。由于水务部门有责任维持饮用水供应的卫生质量，人们对有机微污染物（以微克/升浓度发现的污染物）的存在越来越关注。本研究概述了在评估可能从家庭和工业来源进入水循环的药物化学品风险时遇到的一些问题。在所研究的200种化合物中，分析化学仅对少数几种有价值。然而，许多有用的信息来自药物的人体代谢途径，并整理在附录I中。未来可能在更大程度上需要生物降解研究和其他生态毒性/环境毒理学数据。特别考虑了弱势群体。
