Leaver T M, Shannon H D, Rowe R C
J Pharm Pharmacol. 1985 Jan;37(1):17-21. doi: 10.1111/j.2042-7158.1985.tb04924.x.
A novel particle tracing technique has been used to study the effect of the normal process variables i.e. drum speed, drum loading and the presence/absence of mixing elements (baffles) on the movement of tablets in a side-vented perforated drum (24 in diameter Accela-Cota). The technique involves measuring the duration of light emission from a single luminous tablet using a photomultiplier mounted to scan the same area as a spray gun, and has enabled the quantification of both the time that the tablet spends on the surface per pass (surface time) and the time that the tablet spends within the bulk of the tablet bed (circulation time) over run lengths equating to the normal tablet coating cycle. The technique also allows the study of the uniformity of tablet appearances by means of circulation profiles. It was found that, while both the surface and circulation times decreased with increasing drum speed and loading, there was irregularity of tablet appearance especially at low drum speeds and in the absence of baffles.
一种新型颗粒追踪技术已被用于研究常规工艺变量（即转鼓速度、转鼓装料以及混合元件（折流板）的有无）对侧通风多孔转鼓（直径24英寸的Accela-Cota）中片剂运动的影响。该技术包括使用安装在与喷枪扫描相同区域的光电倍增管测量单个发光片剂的发光持续时间，并能够量化片剂每通过一次在表面停留的时间（表面时间）以及片剂在片剂床体主体内停留的时间（循环时间），运行长度等同于正常片剂包衣周期。该技术还允许通过循环曲线研究片剂外观的均匀性。研究发现，虽然表面时间和循环时间都随着转鼓速度和装料的增加而减少，但片剂外观存在不规则性，尤其是在低转鼓速度和没有折流板的情况下。
