Gyires K, Budavári I, Fürst S, Molnár I
J Pharm Pharmacol. 1985 Feb;37(2):100-4. doi: 10.1111/j.2042-7158.1985.tb05015.x.
Morphine inhibited the oedema formation induced by carrageenan. The anti-inflammatory activity developed 120 min after carrageenan injection, suggesting that inhibition of the kinin phase might be partly responsible. This assumption is supported by the findings that morphine inhibited bradykinin oedema but did not influence oedema formation induced by histamine, 5-HT or PGE2. The anti-inflammatory activity of morphine was partially inhibited by naloxone (0.5-1 mg kg-1) in the carrageenan oedema test. Zymosan-stimulated chemoluminescence of neutrophils of the rat was inhibited both by morphine (0.1-10 microM) and naloxone (1-100 microM). When morphine and naloxone were administered simultaneously (10 microM) their inhibitory effects were additive. Naloxone also failed to antagonize the inhibitory action of morphine in lower dose (0.1 microM). These results suggest that the effect of morphine in inflammation might be mediated either by one of the opiate receptor subtypes insensitive to naloxone or a non-opiate mechanism might be involved.
吗啡抑制了角叉菜胶诱导的水肿形成。抗炎活性在注射角叉菜胶120分钟后显现，这表明对激肽阶段的抑制可能部分起了作用。这一假设得到以下发现的支持：吗啡抑制缓激肽性水肿，但不影响组胺、5-羟色胺或前列腺素E2诱导的水肿形成。在角叉菜胶水肿试验中，纳洛酮（0.5 - 1毫克/千克）部分抑制了吗啡的抗炎活性。酵母聚糖刺激的大鼠中性粒细胞化学发光受到吗啡（0.1 - 10微摩尔）和纳洛酮（1 - 100微摩尔）的抑制。当吗啡和纳洛酮同时给药（10微摩尔）时，它们的抑制作用是相加的。纳洛酮也未能拮抗低剂量（0.1微摩尔）吗啡的抑制作用。这些结果表明，吗啡在炎症中的作用可能是由对纳洛酮不敏感的阿片受体亚型之一介导的，或者可能涉及一种非阿片机制。
