Harrison P J, Newton J M, Rowe R C
J Pharm Pharmacol. 1985 Feb;37(2):81-3. doi: 10.1111/j.2042-7158.1985.tb05011.x.
Surface impairment, in the form of the flow defects roughness and sharkskinning, has been shown to occur with microcrystalline cellulose/lactose/water mixes on extrusion under varying process conditions. These defects result from the imbalance of stresses at the outer wall of the extrudate on leaving the die and can be avoided by changing the process conditions that are known to affect these stresses, e.g. the length of the die, the velocity of throughput and the moisture content of the formulation.
已表明，在不同工艺条件下进行挤压时，微晶纤维素/乳糖/水混合物会出现表面缺陷，表现为流动缺陷、粗糙度和鲨鱼皮现象。这些缺陷是由于挤出物离开模头时外壁应力不平衡造成的，通过改变已知会影响这些应力的工艺条件，如模头长度、产量速度和配方中的水分含量，可以避免这些缺陷。
