Harrison P J, Newton J M, Rowe R C
J Pharm Pharmacol. 1985 Oct;37(10):686-91. doi: 10.1111/j.2042-7158.1985.tb04943.x.
The characterization of the flow of wet powder masses has been achieved using a ram extruder. Force/displacement curves obtained when material is forced through dies of varying length were found to exhibit three stages: (1) compression (2) steady state flow and (3) forced flow. To provide high quality extrudate it was found preferable to ensure that the compression stage was as short as possible and that steady state flow predominated. To produce these conditions, an optimum composition, die length and ram speed were required. The implications of these findings in relation to the provision of suitable formulations and production conditions for the preparation of spherical granules are discussed.
使用活塞式挤出机实现了对湿粉末物料流动特性的表征。当物料被压过不同长度的模头时所获得的力/位移曲线显示出三个阶段：(1) 压缩阶段；(2) 稳态流动阶段；(3) 强制流动阶段。为了获得高质量的挤出物，发现最好确保压缩阶段尽可能短且稳态流动占主导。为了产生这些条件，需要最佳的配方、模头长度和活塞速度。讨论了这些发现对于提供制备球形颗粒的合适配方和生产条件的意义。
