Ragnarsson G, Sjögren J
J Pharm Pharmacol. 1985 Mar;37(3):145-50. doi: 10.1111/j.2042-7158.1985.tb05029.x.
The influence of particle interaction, i.e. friction and bonding, on the net work (NETW) during compaction and on Heckel plots was tested by varying the particle size, the lubrication or the moisture content. The NETW was found to be significantly affected by particle interaction. The yield pressure, calculated from Heckel plots, was far less dependent on particle interaction and appears to be more useful for the evaluation of the deformation properties of materials. The NETW may be useful as a test of inter-lot variations in compaction behaviour of materials, due to its high sensitivity to both inter- and intraparticle properties, good reproducibility and low dependence upon die wall conditions. However, it appears to be a poor measure of the plastic properties of the substance.
通过改变颗粒大小、润滑或水分含量，测试颗粒间相互作用（即摩擦和粘结）对压实过程中的净功（NETW）以及赫克尔图的影响。发现NETW受颗粒间相互作用的显著影响。根据赫克尔图计算出的屈服压力对颗粒间相互作用的依赖性要小得多，似乎对评估材料的变形特性更有用。NETW可能作为材料压实行为批次间差异的一种测试方法，因为它对颗粒间和颗粒内性质都具有高灵敏度、良好的重现性且对模壁条件依赖性低。然而，它似乎不是衡量该物质塑性的好方法。
