Collett A R, Dusting G J, Story D F, Purchase M
J Pharm Pharmacol. 1985 Mar;37(3):188-92. doi: 10.1111/j.2042-7158.1985.tb05037.x.
[3H]Adrenaline was incorporated in an isolated perfused preparation of the rabbit adrenal gland and the effects of indomethacin, PGE2 and PGI2 on its release were investigated. Efflux of [3H]adrenaline was elicited by electrical stimulation of the splanchnic nerve (60 s at 5 Hz). Indomethacin (3 and 30 microM) had no effect on stimulation-induced efflux. PGE2 (30, 90 and 300 nM) reduced the efflux; with 90 nM PGE2 the inhibition amounted to approximately 30%. PGI2, in concentrations from 90 to 600 nM, was without effect. These findings indicate that release of [3H]adrenaline from the rabbit adrenal gland is not subject to modulation by endogenous adrenal prostaglandins; however, PGE2 may play a role in some pathological situations.
将[3H]肾上腺素掺入兔肾上腺的离体灌流制剂中，研究吲哚美辛、前列腺素E2（PGE2）和前列环素（PGI2）对其释放的影响。通过电刺激内脏神经（5Hz，持续60秒）引发[3H]肾上腺素的流出。吲哚美辛（3和30微摩尔）对刺激诱导的流出没有影响。PGE2（30、90和300纳摩尔）减少了流出；90纳摩尔的PGE2时，抑制率约为30%。浓度为90至600纳摩尔的PGI2没有作用。这些发现表明，兔肾上腺中[3H]肾上腺素的释放不受内源性肾上腺前列腺素的调节；然而，PGE2可能在某些病理情况下起作用。
