Pierce V, Shepperson N B, West-Watson A
J Pharm Pharmacol. 1985 Mar;37(3):200-2. doi: 10.1111/j.2042-7158.1985.tb05041.x.
In patas monkeys fed a high cholesterol diet, chronic dosing with the antihypertensive agent indoramin increases the cholesterol ratio by raising the plasma HDL-C concentration. Epidemiological evidence suggests that increasing HDL-C reduces the incidence of coronary heart disease (CHD). If, therefore, indoramin is able to evoke these changes in man it may be expected to favourably influence the progress of CHD.
在喂食高胆固醇饮食的叟猴中,长期服用抗高血压药物吲哚拉明可通过提高血浆高密度脂蛋白胆固醇(HDL-C)浓度来增加胆固醇比值。流行病学证据表明,提高HDL-C可降低冠心病(CHD)的发病率。因此,如果吲哚拉明能够在人体中引发这些变化,那么有望对CHD的病情产生有利影响。