在中国北京男男性行为人群中发现的一种独特的第二代重组形式的HIV-1。
A Unique Second-Generation Recombinant Form of HIV-1 Identified Among Men Who Have Sex with Men Population in Beijing, China.
作者信息
Li Xue, Hao Mingqiang, Hao Yinxiao, Ye Jingrong, Xin Ruolei, Lu Hongyan
机构信息
Institute for AIDS/STD Control and Prevention , Beijing Center for Disease Control and Prevention, Beijing Center for Preventive Medical Research, Beijing, China .
出版信息
AIDS Res Hum Retroviruses. 2017 Oct;33(10):1070-1076. doi: 10.1089/AID.2017.0102. Epub 2017 Jul 5.
In China, CRF01_AE and CRF07_BC are the most circulating strains of HIV-1, more and more second-generation recombinant forms have been isolated around the two strains. The same situation happened in Beijing in recent years. In our study, we have isolated a new second-generation recombinant form of HIV-1 from a male patient who was infected by homosexual behavior. Polygenetic analysis revealed that the sequence includes five CRF01_AE fragments and four CRF07_BC fragments. CRF01_AE is the skeleton of the recombinant which was inserted with four CRF07_BC fragments. The emergency of such second-generation recombinant forms manifests the diversity of the HIV-1 epidemic. Consequently, further investigation of molecular epidemiology is needed to track the genetic evolution of HIV-1.
在中国，CRF01_AE和CRF07_BC是最主要流行的HIV-1毒株，围绕这两种毒株分离出了越来越多的第二代重组形式。近年来北京也出现了同样的情况。在我们的研究中，我们从一名因同性恋行为感染的男性患者中分离出一种新的HIV-1第二代重组形式。多基因分析显示，该序列包含五个CRF01_AE片段和四个CRF07_BC片段。CRF01_AE是重组体的骨架，插入了四个CRF07_BC片段。此类第二代重组形式的出现体现了HIV-1流行的多样性。因此，需要进一步开展分子流行病学调查以追踪HIV-1的基因演变。
Zotero 插件