中国广西男男性行为者中一种新型HIV-1独特重组型在B、CRF01_AE和CRF07_BC之间的鉴定。
Identification of a Novel HIV-1 Unique Recombinant Form Between B, CRF01_AE and CRF07_BC in Men Who Have Sex with Men in Guangxi, China.
作者信息
Kong Desheng, Wang Yan, Wang Chen, Liang Shujia, Feng Yi, Shao Yiming, Ma Liying
机构信息
1 State Key Laboratory of Infectious Disease Prevention and Control, Division of Virology and Immunology, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, China .
2 Guangxi Center for Disease Prevention and Control , Nanning, China .
出版信息
AIDS Res Hum Retroviruses. 2018 Mar;34(3):319-323. doi: 10.1089/AID.2017.0259. Epub 2018 Feb 13.
B, CRF01_AE and CRF07_BC are three major HIV-1 subtypes circulating in China. Here we detected a novel CCR5-tropic HIV-1 recombinant virus (GX2016EU23), which was isolated from an HIV-1-infected man who had sex with men (MSM) in Guangxi, China. Phylogenetic analysis of the near full-length genome showed that GX2016EU23 consisted of at least seven segments, that is two B, two CRF01_AE, and three CRF07_BC segments. Recombinant breakpoints of GX2016EU23 were observed in the gag, pol, rev, and env regions. This is the first detection of a novel HIV-1 recombinant (B/CRF01_AE/CRF07_BC) in MSM in Guangxi. The emergence of this novel recombinant suggests the increasing genetic diversity of the HIV-1 epidemic among the MSM group in China.
B、CRF01_AE和CRF07_BC是在中国流行的三种主要的HIV-1亚型。在此，我们检测到一种新型的CCR5嗜性HIV-1重组病毒（GX2016EU23），它是从中国广西一名与男性发生性行为的HIV-1感染男性（男男性行为者）中分离出来的。对近全长基因组的系统发育分析表明，GX2016EU23至少由七个片段组成，即两个B片段、两个CRF01_AE片段和三个CRF07_BC片段。在gag、pol、rev和env区域观察到GX2016EU23的重组断点。这是在广西男男性行为者中首次检测到新型HIV-1重组体（B/CRF01_AE/CRF07_BC）。这种新型重组体的出现表明中国男男性行为者群体中HIV-1流行的遗传多样性在增加。
Zotero 插件