Wu Li, Huang Ling, Zhang Wangming, Liu Jinhe, Kong Yihua
1 People's Hospital of Zunyi City Bo Zhou District, Zunyi, Guizhou, China.
2 The First Affiliated Hospital of Guiyang University of Chinese Medicine, Guiyang, Guizhou, China.
AIDS Res Hum Retroviruses. 2019 Jul;35(7):664-667. doi: 10.1089/AID.2019.0010. Epub 2019 May 23.
We identified a novel CRF01_AE and 07_BC HIV-1 recombinant form in Guizhou province in southwest China. The phylogenetic analysis of the near full-length sequence reveals that it was divided into five segments by four breakpoints, and the CRF01_AE regions of the recombinant were clustered with subcluster 4 lineage of CRF01_AE, which mainly circulated among men who have sex with men (MSM) in China. The CRF07_BC regions of the recombinant were clustered with CRF07_BC lineage, which circulated among Chinese MSM. This is the first detection of a novel HIV-1 second-generation recombinant form (CRF07_BC/CRF01_AE) in Guizhou, which shows the increasing significance of heterosexual transmission contributing to the complexity of the HIV-1 epidemic in southwest China, and more effort measures should be taken to monitor the genetic evolution of HIV-1 strains and prevent HIV-1 transmissions.
我们在中国西南部的贵州省发现了一种新型的CRF01_AE和07_BC型HIV-1重组形式。对近全长序列的系统发育分析表明，它被四个断点分为五个片段，重组体的CRF01_AE区域与CRF01_AE亚群4谱系聚类，该谱系主要在中国男男性行为者（MSM）中传播。重组体的CRF07_BC区域与CRF07_BC谱系聚类，该谱系在中国男男性行为者中传播。这是在贵州首次检测到新型HIV-1第二代重组形式（CRF07_BC/CRF01_AE），这表明异性传播对中国西南部HIV-1流行复杂性的影响日益显著，应采取更多措施监测HIV-1毒株的基因进化并预防HIV-1传播。
