不同的机制可消除反向重复Alu元件对细胞RNA代谢的潜在毒性作用。
Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism.
作者信息
Elbarbary Reyad A, Maquat Lynne E
机构信息
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, and Center for RNA Biology, University of Rochester, Rochester, New York, USA.
出版信息
Nat Struct Mol Biol. 2017 Jun 6;24(6):496-498. doi: 10.1038/nsmb.3416.
Abstract
RNA-binding proteins are shown in two independent studies to mediate distinct and beneficial effects to cells by binding to the extensive double-stranded RNA structures of inverted-repeat Alu elements. One study reports stress-induced export of ADAR1p110 to the cytoplasm where it binds inverted-repeat Alu elements so as to protect many mRNAs encoding anti-apoptotic proteins from degradation; the other demonstrates binding of the nuclear helicase DHX9 to inverted-repeat Alu elements embedded within RNAs to minimize defects in RNA processing.
摘要
两项独立研究表明，RNA结合蛋白通过与反向重复Alu元件的广泛双链RNA结构结合，对细胞产生不同的有益影响。一项研究报告称，应激诱导ADAR1p110转运至细胞质，在那里它与反向重复Alu元件结合，从而保护许多编码抗凋亡蛋白的mRNA不被降解；另一项研究表明，核解旋酶DHX9与RNA中嵌入的反向重复Alu元件结合，以尽量减少RNA加工中的缺陷。
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