Ahmedah Hanadi Talal, Patterson Laurence H, Shnyder Steven D, Sheldrake Helen M
Radiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia.
Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK.
Cancers (Basel). 2017 May 26;9(6):56. doi: 10.3390/cancers9060056.
Alterations in integrin expression and function promote tumour growth, invasion, metastasis and neoangiogenesis. Head and neck cancers are highly vascular tumours with a tendency to metastasise. They express a wide range of integrin receptors. Expression of the αv and β1 subunits has been explored relatively extensively and linked to tumour progression and metastasis. Individual receptors αvβ3 and αvβ5 have proved popular targets for diagnostic and therapeutic agents but lesser studied receptors, such as αvβ6, αvβ8, and β1 subfamily members, also show promise. This review presents the current knowledge of integrin expression and function in squamous cell carcinoma of the head and neck (HNSCC), with a particular focus on the arginine-glycine-aspartate (RGD)-binding integrins, in order to highlight the potential of integrins as targets for personalised tumour-specific identification and therapy.
整合素表达和功能的改变促进肿瘤生长、侵袭、转移和新血管生成。头颈癌是具有转移倾向的高血管肿瘤。它们表达多种整合素受体。αv和β1亚基的表达已得到较为广泛的研究，并与肿瘤进展和转移相关。个别受体αvβ3和αvβ5已被证明是诊断和治疗药物的热门靶点，但研究较少的受体，如αvβ6、αvβ8和β1亚家族成员，也显示出前景。本综述介绍了目前关于整合素在头颈部鳞状细胞癌（HNSCC）中的表达和功能的知识，特别关注精氨酸-甘氨酸-天冬氨酸（RGD）结合整合素，以突出整合素作为个性化肿瘤特异性识别和治疗靶点的潜力。
